四君子汤为基本方治疗溃疡性结肠炎的Meta分析  

Meta Analysis of Sijunzi Decoction as the Basic Prescription in the Treatment of Ulcerative Colitis

作　　者：邹孟龙 黄晓燕[2] 陈雅璐 宁芯 ZOU Menglong;HUANG Xiaoyan;CHEN Yalu;NING Xin(Graduate School of Guangxi University of Traditional Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学研究生院,南宁530001 [2]广西中医药大学第一附属医院,南宁530023

出　　处：《世界中医药》2021年第24期3624-3628,3632,共6页World Chinese Medicine

基　　金：国家自然科学基金项目(81460714)——端粒短缩介导上皮细胞凋亡参与溃疡性结肠炎相关癌变及四君子汤干预研究;广西创新驱动发展专项(桂科AA17202031)——健脾益气口服液的开发研究。

摘　　要：目的:评估四君子汤为基本方的方药治疗溃疡性结肠炎(UC)的疗效。方法:检索7个医学常用数据库,收集四君子汤治疗UC的随机对照试验,时限均为建库至2020年3月,然后对数据进行整理和分析。结果:共纳入22项研究,包括1862例患者。Meta分析显示:与常规西药治疗比较,四君子汤为基本方的方药能提高内镜疗效(OR=3.76,95%CI为2.83~5.00,P<0.00001)、中医证候疗效(OR=3.08,95%CI为1.21~7.87,P=0.02);改善血清肿瘤坏死因子α表达(MD=-5.21,95%CI为-6.86~-3.56,P<0.00001)、血清白细胞介素-33表达(MD=-1.10,95%CI为-1.28~-0.92,P<0.00001)、血清超氧化物歧化酶表达(MD=107.64,95%CI为84.14~131.14,P<0.00001)以及降低不良反应发生率(OR=0.37,95%CI为0.15~0.94,P=0.04)。结论:四君子汤为基本方的方药治疗溃疡性结肠炎可显著提高临床疗效,改善血清炎症介质、超氧化物歧化酶表达,且安全性高。Objective:To evaluate the efficacy of Sijunzi Decoction in the treatment of ulcerative colitis(UC).Methods:A total of 7 commonly used medical databases were searched by computer,and the randomized controlled trials of Sijunzi Decoction in the treatment of UC were collected,all of which were built from March to March 2020,and then the data were collected and analyzed.Results:A total of 22 studies were included,including 1862 patients.The results of Meta analysis showed that compared with conventional Western medicine,the prescription with Sijunzi Decoction as the basic prescription could improve the curative effect of endoscope[OR=3.76,95%CI(2.83 to 5.00),P<0.00001]and the curative effect of traditional Chinese medicine symptoms[OR=3.08,95%CI(1.21 to 7.87),P=0.02],improve the expression of serum tumor necrosis factor-α[MD=-5.21,95%CI(-6.86 to-3.56),P<0.00001],the expression of serum interleukin-33[MD=-1.10,95%CI(-1.28 to-0.92),P<0.00001],the expression of serum superoxide dismutase[MD=107.64,95%CI(84.14 to 131.14),P<0.00001],and reduce the incidence of adverse reactions[OR=0.37,95%CI(0.15 to 0.94),P=0.04].Conclusion:Sijunzi Decoction as the basic prescription in the treatment of ulcerative colitis can significantly improve the clinical efficacy,improve the expression of serum inflammatory mediators and superoxide dismutase,and has high safety.

关 键 词：四君子汤 溃疡性结肠炎 META分析 系统评价 随机对照试验 肿瘤坏死因子Α 白细胞介素-33 超氧化物歧化酶 

分 类 号：R256.33[医药卫生—中医内科学] R256.34[医药卫生—中医学]