Effects of soy hull polysaccharide on dyslipidemia and pathoglycemia in rats induced by a high-fat-high-sucrose diet  

作　　者：Qian Lin Lina Yang Lin Han Ziyi Wang Mingshuo Luo Danshi Zhu He Liu Xin Li Yu Feng 

机构地区：[1]College of Food Science and Technology,Bohai University,Jinzhou 121013,China [2]National&Local Joint Engineering Research Center of Storage,Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products,Jinzhou 121013,China

出　　处：《Food Science and Human Wellness》2022年第1期49-57,共9页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant No.31901680 and 31972031).

摘　　要：The present work aimed at investigating the effects of soy hull polysaccharide(SHP)in alleviating adverse effects in rats fed a high-fat-high-sucrose diet.After SHP feeding for 4 weeks,the fasting blood glucose(FBG),serum triglyceride(TG),serum high-density lipoprotein cholesterol(HDL-C),short chain fatty acids(SCFAs),and 16S rDNA gene sequence were determined.Administration of SHP significantly decreased body fat content and TG levels,and increased water intake and HDL-C levels after 4 weeks of treatment.The antihyperglycemic effect of SHP at a dose of 400 mg/kg mb had the most significant effects among the three dosage groups.SHP notably restored the FBG in rats fed a high-fat-high-sucrose diet(P<0.05).Furthermore,SHP at 400 mg/kg mb increased the abundance of Bacteroidetes and decreased that of Firmicutes and Actinobacteria at the phylum level.The polysaccharide treated groups had significantly higher content of total SCFAs,and the main fermentation products were acetic,propionic,n-valeric and i-valeric acids.Thus,SHP restores blood lipid levels in rats fed a high-fat-high sucrose diet through regulation of the gut microbiota.

关 键 词：Soy hull polysaccharide ANTIHYPERLIPIDEMIC Gut microbiota Short-chain fatty acids 

分 类 号：TS210.9[轻工技术与工程—粮食、油脂及植物蛋白工程]