多囊卵巢综合征患者妊娠期体内维生素D水平与血脂代谢以及妊娠结局的关系  

Relationship between vitamin D level and blood lipid metabolism,pregnancy outcome in patients with polycystic ovary syndrome during gestational period

作　　者：李婷[1] 李雪倩[2] 尹东升 LI Ting;LI Xueqian;YIN Dongsheng(Department of Endocrinology,Shangluo Central Hospital,Shangluo 726000,China)

机构地区：[1]商洛市中心医院内分泌科,陕西商洛726000 [2]西安交通大学第二附属医院内分泌科,陕西西安710004

出　　处：《陕西医学杂志》2022年第1期55-58,共4页Shaanxi Medical Journal

基　　金：陕西省重点研发计划项目(2017SF-171)。

摘　　要：目的:探讨多囊卵巢综合征(PCOS)患者妊娠期体内维生素D水平与血脂代谢以及妊娠结局的关系,从而为患者的临床诊疗提供指导。方法:选取接受治疗的50例妊娠期患有PCOS的妇女作为观察组,并选取同期接受产检的50例正常妊娠期孕妇作为对照组。①记录并比较两组血清维生素D水平;②对两组血脂代谢相关指标进行比较,主要包括甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)以及高密度脂蛋白胆固醇(HDL-C);③分析血清维生素D水平与血脂代谢之间的相关性;④比较两组对象分娩情况,主要包括早产、剖宫产、羊水过多、羊水过少、胎盘早破、产后出血等;⑤比较两组胎儿预后情况,包括新生儿窒息、新生儿畸形、巨大儿、新生儿低血糖、低体重儿等。结果:①与对照组相比,观察组患者体内TG、TC水平明显较高,观察组患者体内维生素D、LDL-C以及HDL-C水平低于对照组,且组间差异具有统计学意义(均P<0.05);②Pearson相关分析显示,研究对象TG水平与维生素D水平呈负相关(r=-0.443,P=0.000),TC水平与维生素D水平呈负相关(r=-0.233,P=0.019),LDL-C以及HDL-C水平与维生素D水平无相关性(均P>0.05);③观察组患者剖宫产、羊水过多、羊水过少以及胎盘早破的发生率均高于对照组,但组间差异无统计学意义(均P>0.05),与对照组相比,观察组患者早产和产后出血的发生率较高,且组间差异具有统计学意义(P<0.05);④观察组患者新生儿窒息、新生儿畸形、巨大儿、新生儿低血糖等发生例数均高于对照组,但组间差异无统计学意义(均P>0.05),与对照组相比,观察组患者低体重儿例数较高,且组间差异具有统计学意义(P<0.05)。结论:与正常处于妊娠期的孕妇相比,患PCOS的妊娠期妇女体内维生素D水平明显降低,加重了患者自身的血脂代谢紊乱,且对孕妇的分娩情况以及胎儿预后情况具有一定影响。Objective:To explore the relationship between vitamin D level and blood lipid metabolism,pregnancy outcome in patients with polycystic ovary syndrome(PCOS)during gestational period,so as to provide guidance for the clinical diagnosis and treatment.Methods:50 pregnant women with PCOS were selected as the observation group,and 50 normal pregnant women who underwent prenatal examination in the same period were selected as the control group.The serum vitamin D levels of the two groups were recorded and compared.The indexes related to blood lipid metabolism were compared between the two groups,mainly including triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C).The correlation between serum vitamin D level and blood lipid metabolism was analyzed.The delivery conditions of the two groups were compared,mainly including premature delivery,cesarean section,polyhydramnios,oligohydramnios,premature rupture of placenta,postpartum hemorrhage and so on.The fetal prognosis of the two groups was compared,including neonatal asphyxia,neonatal malformation,macrosomia,neonatal hypoglycemia,low body weight infants and so on.Results:Compared with the control group,the levels of TG and TC in the observation group were significantly higher,and the levels of vitamin D,LDL-C and HDL-C in the observation group were lower than those in the control group(all P<0.05).Pearson correlation analysis showed that TG level was negatively correlated with vitamin D level(r=-0.443,P=0.000),TC level was negatively correlated with vitamin D level(r=-0.233,P=0.019),and LDL-C and HDL-C levels were not correlated with vitamin D level(P>0.05).The incidence of cesarean section,polyhydramnios,oligohydramnios and placental rupture in the observation group were higher than those in the control group,but there was no significant difference between the groups(all P>0.05).Compared with the control group,the incidence of preterm birth and postpartum hemorrhage in the observation group were

关 键 词：多囊卵巢综合征 妊娠期 维生素D 血脂代谢 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]