小剂量阿司匹林与佩尔地平联合高压氧治疗早发型重度子痫前期对患者血清内脂素、氧化修饰低密度脂蛋白水平变化及妊娠结局的影响  

Effects of low-dose aspirin and perdipine combined with hyperbaric oxygen in treatment of early onset severe preeclampsia on levels of serum visfatin,oxidized low-density lipoprotein and pregnancy outcome

作　　者：尤正芳 金红梅 YOU Zhengfang;JIN Hongmei(Qingpu Branch,Zhongshan Hospital Affiliated to Fudan University,Shanghai 201700,China)

机构地区：[1]上海复旦大学附属中山医院青浦分院产科,上海201700

出　　处：《陕西医学杂志》2022年第1期84-87,共4页Shaanxi Medical Journal

摘　　要：目的:探讨小剂量阿司匹林与佩尔地平联合高压氧对早发型重度子痫前期(EOSP)患者血清内脂素(Visfatin)、氧化修饰低密度脂蛋白(ox-LDL)水平变化及妊娠结局的影响。方法:选取EOSP患者98例,抽签法分组各49例。对照组予以小剂量阿司匹林和佩尔地平治疗,观察组于对照组基础上联合高压氧治疗,均持续治疗7 d。比较两组治疗效果及妊娠结局,并对比两组治疗前、治疗7 d后平均动脉压水平、24 h尿蛋白定量及血清Visfatin、ox-LDL水平。结果:治疗7 d后观察组总有效率93.88%(46/49)高于对照组75.51%(37/49),比较差异有统计学意义(P<0.05);观察组妊娠维持时间、新生儿体重高于对照组,新生儿窒息发生率低于对照组,比较差异有统计学意义(均P<0.05);治疗前两组平均动脉压水平及24 h尿蛋白定量比较差异无统计学意义(均P>0.05),治疗7 d后与对照组相比,观察组平均动脉压水平及24 h尿蛋白定量均降低,差异有统计学意义(均P<0.05);治疗7 d后观察组血清Visfatin、ox-LDL水平均低于对照组,差异有统计学意义(均P<0.05)。结论:EOSP患者予以小剂量阿司匹林与佩尔地平联合高压氧治疗效果显著,可有效降低患者蛋白尿、血压及降低血清Visfatin、ox-LDL水平,改善妊娠结局。Objective:To explore the effects of low-dose aspirin and perdipine combined with hyperbaric oxygen in the treatment of early onset severe preeclampsia(EOSP)on levels of serum visfatin,oxidized low-density lipoprotein(ox-LDL)and pregnancy outcome.Methods:98 patients with EOSP were divided into two groups with 49 cases each.The control group was treated with low-dose aspirin and perdipine,and the observation group was treated with hyperbaric oxygen therapy on the basis of the control group.All the patients were treated continuously for 7 days.The treatment effect and pregnancy outcome were compared between the two groups.The average arterial pressure level,24-hour urinary protein level,serum visfatin and ox-LDL levels before treatment and 7 days after treatment were compared between the two groups.Results:After 7 days of treatment,the total effective rate of the observation group was 93.88%(46/49),higher than 75.51%(37/49)of the control group(P<0.05).The duration of pregnancy and neonatal weight of the observation group were higher than those of the control group,and the incidence of neonatal asphyxia was lower than that of the control group(all P<0.05).There was no significant difference between the two groups in the average arterial pressure level and the 24h urine protein before treatment(all P>0.05).After 7 days of treatment,compared with the control group,the average arterial pressure level and 24-hour urine protein in the observation group were decreased(all P<0.05).After 7 days of treatment,the serum visfatin and ox-LDL levels of the observation group were lower than those of the control group(all P<0.05).Conclusion:The effect of low-dose aspirin and perdipine combined with hyperbaric oxygen in patients with EOSP is significant.It can effectively reduce the levels of proteinuria,blood pressure,serum visfatin and ox-LDL,and improve the pregnancy outcome.

关 键 词：早发型重度子痫前期 阿司匹林 佩尔地平 高压氧 妊娠结局 内脂素 氧化修饰低密度脂蛋白 

分 类 号：R714.2[医药卫生—妇产科学]