长脉宽1064nm Nd:YAG激光与2940nm点阵激光联合外用类人胶原蛋白治疗眶周静态纹疗效观察  

Observation on Clinical Efficacy of Long-pulse 1064nm Nd:YAG Laser and 2940nm Fractional Laser Combined with Human-like Collagen in Treatment of Periorbital Static Wrinkles

作　　者：梁春霞 连石 冉从华 齐婧 LIANG Chun-xia;LIAN Shi;RAN Cong-hua;QI Jing(Department of Dermatology,Beijing Leader Medical Cosmetology Hospital,Beijing 100012,China;Department of Dermatology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]北京丽都医疗美容医院皮肤科,北京100012 [2]中国人民解放军总医院第一医学中心皮肤科,北京100853

出　　处：《中国美容医学》2021年第12期71-74,共4页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨长脉宽1064nm Nd:YAG激光与2940nm Er:YAG点阵激光联合外用类人胶原蛋白治疗眶周静态皱纹的疗效及安全性。方法:选取28例不同程度眶周静态皱纹的患者为研究对象,采用长脉宽1064nm Nd:YAG激光与2940nm Er:YAG点阵激光联合外用类人胶原蛋白治疗,治疗间隔1个月,共治疗3次,分别于治疗前(V0)、疗程结束后1个月(V1)、疗程结束后3个月(V2)进行VISIA拍摄,记录患者眶周静态纹改善情况,并由两名医师对患者进行Fitzpatrick皮肤皱纹分级及疗效评估,同时记录治疗不良反应情况。结果:28例患者均完成了3次治疗,V0、V1、V2左侧眶周静态纹特征计数分别为60.57±32.66、42.86±27.8、32.57±20.37;皱纹分值为17.12±10.11、11.15±7.24、9.44±6.23;皱纹百分数为0.81±0.18、0.92±0.06、0.93±0.06;皱纹分级为3.93±1.07、2.93±1.07、2.50±1.16,右侧眶周静态纹特征计数为73.29±41.68、51.43±31.11、41.43±24.10;皱纹分值为21.91±13.39、16.30±8.51、11.63±9.19;皱纹百分数为0.68±0.25、0.83±0.17、0.90±0.11;皱纹分级为4.07±1.07、3.14±1.03、2.79±0.89,V1、V2疗效评估左侧分别为1.50±0.65、2.00±0.55;右侧为1.50±0.65、2.36±0.63。双侧眶周V0、V1、V2的皱纹特征计数、皱纹分值、皱纹百分数、皱纹分级比较及V1、V2疗效评估比较差异均有统计学意义(P<0.05)。结论:长脉宽1064nm Nd:YAG激光与2940nm Er:YAG点阵激光联合外用类人胶原蛋白治疗眶周静态皱纹安全、有效且舒适。Objective To evaluate the clinical efficacy of long-pulse 1064nm Nd:YAG laser and 2940nm Er:YAG fractional laser combined with Human-like Collagen in treatment of periorbital static wrinkles.Methods A total of 28 patients with periorbital static wrinkles treated in our outpatient department were selected as study subjects.All patients were treated with Long-pulse 1064nm Nd:YAG laser and 2940nm Er:YAG fractional laser combined with Human-like Collagen.The treatment interval was 1 month,and there were total 3 treatments.VISIA was performed at the time before the 1st treatment(V0),1 month(V1)after the end of the treatment and 3 months(V2)after the end of the treatment.Fitzpatrick wrinkle grade and efficacy evaluation were performed by 2 physicians,and the adverse reactions of the treatment were recorded.Results All patients completed 3 treatments.V0,V1,V2 moments,left-hand periorbital static wrinkles characteristics count was 60.57±32.66,42.86±27.8,32.57±20.37,the wrinkle score was 17.12±10.11,11.15±7.24,9.44±6.23,the wrinkle percentage was 0.81±0.18,0.92±0.06,0.93±0.06,the Fitzpatrick wrinkle grade was 3.93±1.07,2.93±1.07,2.50±1.16.V0,V1,V2 moments,right-hand periorbital static wrinkles characteristics count was 73.29±41.68,51.43±31.11,41.43±24.10,the wrinkle score was 21.91±13.39,16.30±8.51,11.63±9.19,the wrinkle percentage was 0.68±0.25,0.83±0.17,0.90±0.11,the Fitzpatrick wrinkle grade was 4.07±1.07,3.14±1.03,2.79±0.89.V1,V2 moment,efficacy assessment on left-hand was 1.50±0.65,2.00±0.55,on right-hand was 1.50±0.65,2.36±0.63.There were statistically significant differences in periorbital wrinkle features,wrinkle score,wrinkle percentage,Fitzpatrick wrinkle grade and efficacy evaluation(P<0.05)at V0,V1 and V2 on each side.Conclusion Long-pulse 1064nm Nd:YAG laser and 2940nm Er:YAG fractional laser combined with Human-like Collagen is a safe,effective and comfortable treatment for static wrinkles around the ripples.

关 键 词：ND:YAG激光 Er:YAG点阵激光 类人胶原蛋白 眶周静态纹 

分 类 号：R616.4[医药卫生—外科学]