复方甘草酸苷片配合米诺地尔酊治疗斑秃的效果及对血清细胞因子Anti-TPOAb和Anti-TGAb水平的影响  

Effect of Compound Glycyrrhizin Tablets Combined with Minoxidil Tincture in the Treatment of Alopecia Areata and the Influence on Serum Levels of Anti-TPOAb and Anti-TGAb

作　　者：杨今言[1] 杨敏 陈赵慧[1] 卢娟[1] 李丽华[1] YANG Jin-yan;YANG Min;CHEN Zhao-hui;LU Juan;LI Li-hua(Department of Dermatology,the Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830064,Xinjiang,China)

机构地区：[1]新疆医科大学第二附属医院皮肤科,新疆乌鲁木齐830064

出　　处：《中国美容医学》2021年第12期93-97,共5页Chinese Journal of Aesthetic Medicine

基　　金：新疆维吾尔自治区自然科学基金(编号:2020D01C226)。

摘　　要：目的:探究复方甘草酸苷片配合米诺地尔酊治疗斑秃的临床价值及对甲状腺自身抗体水平的影响。方法:选取2017年2月-2019年10月收治的斑秃患者89例,按就诊编号奇偶数分为对照组与观察组,分别为44例与45例,两组均予米诺地尔酊外用,观察组加用复方甘草酸苷片,疗程为12周。比较两组治疗效果;治疗前、治疗3个月均行毛发镜检查,测定毛囊密度、毛发密度、毳毛率;并采血检测外周血白介素-10(IL-10)、干扰素-γ(IFN-γ)、转化生长因子-β(TGF-β)、P物质(SP)及甲状腺自身抗体抗甲状腺球蛋白抗体(Anti-TGAb)、抗甲状腺过氧化酶抗体(Anti-TPOAb)与甲状腺激素促甲状腺素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)水平的变化;统计治疗不良反应发生情况及随访6个月复发情况。结果:观察组疗效优于对照组(95.56%vs 86.36%),差异有统计学意义(P<0.05)。治疗12周后,观察组毛囊密度、毛发密度高于对照组[(92.25±10.14)cm^(2)、(129.52±10.96)cm^(2)vs(86.52±7.98)cm^(2)、(123.35±11.75)cm^(2)],毳毛率低于对照组[(8.25±2.14)%vs(11.36±3.33)%],差异有统计学意义(P<0.05)。治疗12周后,观察组IL-10、TGF-β高于对照组[(89.52±10.55)pg/ml、(53.52±7.25)ng/ml vs(84.75±8.51)pg/ml、(50.63±5.44)ng/ml],IFN-γ、SP低于对照组[(28.41±5.15)ng/L、(10.52±3.06)pg/ml vs(33.65±6.98)ng/L、(13.25±4.17)pg/ml],差异有统计学意义(P<0.05)。两组治疗前后Anti-TGAb阳性率及TSH、FT3、FT4水平比较差异无统计学意义(P>0.05);治疗12周后,观察组Anti-TPOAb阳性率降低,与同组治疗前比较差异有统计学意义(P<0.05),与对照组治疗后比较差异无统计学意义(P>0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。观察组随访6个月斑秃复发率(6.67%)低于对照组(22.73%),差异有统计学意义(P<0.05)。结论:复方甘草酸苷片配合米诺地尔酊联合治疗斑秃整体价值优于单独应用米诺地尔酊,Objective To investigate the clinical value of compound glycyrrhizin tablets combined with minoxidil tincture in the treatment of alopecia areata and the influence on levels of thyroid autoantibodies.Methods Eighty-nine patients with alopecia areata were selected and divided into the control group(44 cases)and the observation group(45 cases).All subjects were treated with external application of minoxidil tincture,and patients in observation group were additionally treated with compound glycyrrhizin tablets for 12 weeks.Therapeutic effects of the two groups were compared,and trichoscopy was performed before treatment and after treatment.The follicle density,hair density and vellus hair rate were determined.Blood samples were collected to detect changes in levels of peripheral blood interleukin-10(IL-10),interferon-γ(IFN-γ),transforming growth factor-β(TGF-β),substance P(SP),thyroid autoantibodies[anti-thyroglobulin antibody(Anti-TGAb),anti-thyroid peroxidase antibody(Anti-TPOAb)],thyroid hormones[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free thyroxine(FT4)].The occurrence of adverse reactions and recurrence during 6 months of follow-up were statistically analyzed.Results The curative effect of the observation group was better than that of the control group(95.56%vs 86.36%),the difference was statistically significant(P<0.05).After 12 weeks of treatment,the hair follicle density and hair density in the observation group were higher than those in the control group[(92.25±10.14)cm^(2),(129.52±10.96)cm^(2) vs(86.52±7.98)cm^(2),(123.35±11.75)cm^(2)],and the hairiness rate was lower than that in the control group[(8.25±2.14)%vs(11.36±3.33)%],the differences were statistically significant(P<0.05).After 12 weeks of treatment,IL-10 and TGF-βin the observation group higher than the control group[(89.52±10.55)pg/ml,(53.52±7.25)ng/ml vs(84.75±8.51)pg/ml,(50.63±5.44)ng/ml],IFN-γand SP was lower than those in the control group[(28.41±5.15)ng/L,(10.52±3.06)pg/ml vs(33.65±6.98)ng/L,(13.25±4

关 键 词：斑秃 复方甘草酸片 米诺地尔酊 甲状腺自身抗体 甲状腺激素 毛发镜 

分 类 号：R758.71[医药卫生—皮肤病学与性病学]