吸烟成瘾男性脑静态及动态低频振幅的功能磁共振研究  

Functional magnetic resonance study on static and dynamic amplitude of low frequency fluctuation in male smoking addicts

作　　者：高昕宇 张勇[1] 文萌萌 张孟哲 杨镇圭 黄荟玉 汪卫建 程敬亮[1] Gao Xinyu;Zhang Yong;Wen Mengmeng;Zhang Mengzhe;Yang Zhengui;Huang Huiyu;Wang Weijian;Cheng Jingliang(Department of MR,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450002,China)

机构地区：[1]郑州大学第一附属医院磁共振科,450002

出　　处：《中华行为医学与脑科学杂志》2021年第12期1077-1081,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家重点研发计划项目(SQ2018YFC130095);河南省科技攻关项目(172102310391);河南省重点研发与推广专项(科技攻关)支持项目(212102310712)。

摘　　要：目的比较吸烟成瘾男性与健康对照组静态及动态自发性脑活动的差异,探索吸烟成瘾机制。方法基于静态低频振幅(static amplitude of low frequency fluctuation,sALFF)和动态低频振幅(dynamic amplitude of low frequency fluctuation,dALFF)方法,采用独立样本t检验比较男性吸烟成瘾组(n=63)和健康对照组(n=30)静态及动态脑自发活动差异。采用Pearson相关分析探讨吸烟成瘾组dALFF值的变化与烟草依赖评估得分(Fagerström test for nicotine dependence,FTND)、吸烟指数(包年数)的相关性。结果与健康对照组相比,吸烟成瘾组在左侧额上/中/下回、左侧眶额回(t=5.17,升高区≥108个)区域sALFF活动增加;在右侧颞上/中回、左侧额眶区、左侧眶部额上/中/下回、右侧眶额回/额中/下回、右侧壳核(t=4.90,4.37,4.91,4.62,4.59,变异区≥96个)dALFF变异性增加。吸烟成瘾组右侧颞上/中回(r=0.252,P=0.047)、左侧眶部额上回(r=0.281,P=0.026)、右侧壳核(r=0.313,P=0.012)dALFF的时间变异性与吸烟指数呈正相关。结论吸烟成瘾者静息状态下前额叶皮层(包括眶额叶)、壳核、颞上/中回的脑固有自发神经活动和动态自发神经活动强度增加,且这些脑区功能活动改变与吸烟成瘾者吸烟指数有关。Objective To explore the differences of static and dynamic spontaneous brain activity between male smoking addicts and healthy controls,and analyze the mechanism of smoking addiction.Methods Based on static amplitude of low-frequency fluctuation(sALFF)and dynamic amplitude of low frequency fluctuation(dALFF),the differences of static and dynamic spontaneous brain activity were compared between male smoking addicts(n=63)and healthy controls(n=30)by independent sample t-test.Pearson correlation analysis was used to investigate the relationships between the altered dALFF values and score of Fagerström test for nicotine dependence(FTND)and pack-years of smoking addicted males.Results Compared with healthy controls,the values of sALFF in the left superior/middle/inferior orbitofrontal gyrus(t=5.17,clusters≥108)were increased and the variation of dALFF in the right superior temporal/middle gyrus,left orbitofrontal region,left orbital superior/middle/inferior frontal gyrus,right orbitofrontal gyrus/middle/inferior frontal gyrus and right putamen(t=4.90,4.37,4.91,4.62,4.59,clusters≥96)were also increased in the smoking addicted group.It was noteworthy that the dALFF values of the right superior temporal/middle gyrus(r=0.252,P=0.047),left orbital region superior frontal gyrus(r=0.281,P=0.026)and right putamen(r=0.313,P=0.012)were positively correlated with pack-years of male smoking addicts.Conclusion Male smoking addicts may have abnormal static and dynamics spontaneous neural activity in prefrontal cortex(including orbital frontal lobe),putamen and superior temporal/middle gyrus,which are correlated with pack-years.

关 键 词：吸烟 磁共振成像 低频振幅 男性 物质成瘾 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.6[医药卫生—诊断学]