徐荣谦教授治疗多发性抽动症的组方规律与疗效评价研究  

Prof.Xu Rongqian’s prescription rules and efficacy evaluation for treatment of Tourette Syndrome

作　　者：严雪儿 李杰[1] 吴凤芝[1] 贾鹰珏[2] 陈光耀[1] 郑思思 刘燕[1] 周芹[1] 葛肖波 李峰[1] 宋月晗[1] Yan Xue’er;Li Jie;Wu Fengzhi;Jia Yingyu;Chen Guangyao;Zheng Sisi;Liu Yan;Zhou qin;Ge Xiaobo;Li Feng;Song Yuehan(Beijing University of Chinese Medicine,Beijing 100029;Wangjing Hospital,China Academy of Chinese Medical Sciences;Beijing Anding Hospital Affiliated to Capital Medical University)

机构地区：[1]北京中医药大学,北京100029 [2]中国中医科学院望京医院 [3]首都医科大学附属北京安定医院

出　　处：《现代中医临床》2021年第6期41-45,共5页Modern Chinese Clinical Medicine

基　　金：国家自然科学基金面上项目(No.81874427);北京中医药科技发展资金项目(No.JJ2016-81)。

摘　　要：目的基于数据挖掘探讨徐荣谦教授治疗多发性抽动症的组方规律,以及以温胆汤为主方的疗效评价研究。方法纳入东直门医院符合多发性抽动症诊断标准的首诊病例157例,基于关联规则分析用药规律。纳入30例符合《精神疾病诊断与统计手册》(DSM-IV-TR)的多发性抽动症患者,经徐荣谦教授辨证后开具以温胆汤为基础方的方药,收集并对比治疗前后患者的耶鲁综合抽动严重程度量表(yale global tic severityb scale,YGTSS)评分。结果对157例患者选用方药关联结果进行分析,置信度及支持度较高的配伍主要集中在温胆汤的药物,多配合使用镇肝息风药物石决明、生龙齿、钩藤以及养心安神药物炒酸枣仁、蕤仁。30例患者治疗后YGTSS总分及各子项包括次数、频率、强度、复杂性、干扰、缺损的得分均低于治疗前,差异具有统计学意义(P<0.05)。结论以温胆汤为基础方治疗多发性抽动症具有较好的临床疗效。Objective To explore Prof.Xu Rongqian’s prescription rules in the treatment of Tourette Syndrome(TS)based on data mining and to explore the curative effect evaluation study of Wendan Decoction as the main prescription.Methods One hundred and fifty-seven first-diagnosed cases that met the diagnostic criteria were included,and Professor Xu’s medication rules were explored based on association rules.Thirty patients diagnosed as having TS by using Diagnostic and Statistical Manual of Mental Disorders(DSM-IV-TR)were treated with herb formulas based on Professor Xu Rongqian’s application of modified Wendan Decoction.The scores of The Yale Global Tic Severity Scale(YGTSS)before and after treatment were observed.Results The association of prescriptions and medicines selected by 157patients was analyzed,The compatibility with higher confidence and support was mainly concentrated on the medicines of Wendan Decoction,and the combined use of the live-calming and wind-relieving medicinals,for example,shijueming(Concha Haliotidis),sheng longchi(raw Dens Draconis),gouteng(Ramulus Uncariae Cum Uncis)andmind-tranquilizing medicinals such as chao suanzaoren(fried Semen Ziziphi Spinosae)and ruiren(Nux Prinsepiae).The total score and six dimensions including number,frequency,intensity,complexity,interference and damage scores of YGTSS were all significantly lower after treatment than before treatment(P<0.05).Conclusions Professor Xu’s application of modified Wendan Decoction as basic herb formulas has a good effect in the treatment of Tourette Syndrome.

关 键 词：徐荣谦 多发性抽动症 温胆汤 耶鲁综合抽动严重程度量表 关联分析 

分 类 号：R272.6[医药卫生—中医儿科学]