皮肤移植物抗宿主病发病机制研究进展  

Research progress on pathogenesis of skin graft-versus-host disease

作　　者：李小燕 葸瑞 白海 Li Xiaoyan;Xi Rui;Bai Hai(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou 730000,China;不详)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]中国人民解放军联勤保障部队第九四〇医院血液科

出　　处：《器官移植》2022年第1期120-125,共6页Organ Transplantation

基　　金：甘肃省重大专项项目(1102FKDA005)。

摘　　要：移植物抗宿主病(GVHD)是目前造成异基因造血干细胞移植广泛应用的主要阻碍,是一种可以累及皮肤、肝脏、肺脏、胃肠道等全身各个系统的并发症,其中皮肤是最易受累的器官。目前,皮肤GVHD的发病机制尚未完全阐明,且缺乏有效的治疗手段。重度或广泛型慢性GVHD极大地影响受者的生活质量,因此研究皮肤GVHD的发病机制,从中找到新的治疗方法非常迫切。研究发现白细胞介素(IL)-22、IL-17、IL-6和干扰素(IFN)-γ等细胞因子在皮肤GVHD的发生中扮演重要的角色,但具体作用机制仍不够明确。因此,本文就国内外关于这些细胞因子在皮肤GVHD中的作用机制研究进展做一综述,以期为皮肤GVHD的预防和治疗提供新的思路。Graft-versus-host disease(GVHD)is a major cause that prevents widespread application of allogeneic hematopoietic stem cell transplantation.GVHD is a complication that can affect all systems of the body,such as skin,liver,lung and gastrointestinal tract,among which skin is the most vulnerable organ.At present,the pathogenesis of skin GVHD has not been fully elucidated,and no effective treatment has been established.Severe or extensive chronic GVHD significantly affects the quality of life of the recipients.Consequently,it is urgent to unravel the pathogenesis of skin GVHD and explore novel therapeutic treatment.Cytokines,such as interleukin(IL)-22,IL-17,IL-6 and interferon(IFN)-γ,have been proven to play pivotal roles in the progression of skin GVHD.Nevertheless,the specific mechanism remains elusive.In this article,research progresses at home and abroad on the mechanism underlying the roles of these cytokines in skin GVHD were reviewed,aiming to provide novel ideas for the prevention and treatment of skin GVHD.

关 键 词：造血干细胞移植 移植物抗宿主病 白细胞介素-22 白细胞介素-17 白细胞介素-6 干扰素-γ 信号传导和转录激活因子(STAT) 巴瑞替尼 鲁索利替尼 

分 类 号：R617[医药卫生—外科学] R751[医药卫生—临床医学]