氧化应激反应在边缘供肝肝移植缺血-再灌注损伤中的作用研究进展  

Research progress on the role of oxidative stress in ischemia-reperfusion injury of marginal donor liver transplantation

作　　者：高伟东 杨龙龙[1] 尹清臣[1] Gao Weidong;Yang Longlong;Yin Qingchen(The First Department of General Surgery,Handan Central Hospital,Handan 056004,China)

机构地区：[1]邯郸市中心医院普外一科,河北邯郸056004

出　　处：《器官移植》2022年第1期126-131,共6页Organ Transplantation

基　　金：河北省重点研发计划(182777241)。

摘　　要：常见的边缘供肝主要包括脂肪变性供肝、高龄供肝、小体积供肝、心脏死亡器官捐献(DCD)供肝等。边缘供肝的应用可在一定程度上解决供肝数量严重短缺的问题,但边缘供肝面临着缺血-再灌注损伤(IRI)的难题,且IRI程度相比正常供肝更加严重,是导致移植失败的重要原因,其中氧化应激反应又是引起边缘供肝IRI的重要因素。因此如何减少氧化应激反应及解决边缘供肝IRI的难题成为临床研究的热点问题。活性氧簇(ROS)介导的氧化应激反应贯穿IRI整个过程,本文就氧化应激反应在边缘供肝肝移植IRI中的作用及以ROS为靶点的防治进行综述,以期为临床提供参考。Common marginal donor liver mainly consists of fatty donor liver,elderly donor liver,small volume donor liver and liver graft from donation after cardiac death(DCD),etc.The application of marginal donor liver may resolve the severe shortage of donor liver to certain extent.Nevertheless,marginal donor liver yields a higher risk of ischemia-reperfusion injury(IRI)and causes more severe IRI than normal donor liver,which is a main cause for the failure of transplantation.In addition,oxidative stress is a major risk factor causing IRI of marginal donor liver.Therefore,how to mitigate oxidative stress and alleviate IRI of marginal donor liver has become a hot spot in clinical practice.Reactive oxygen species(ROS)-mediated oxidative stress occurs throughout the whole process of IRI.In this article,the role of oxidative stress in IRI of marginal donor liver transplantation and the ROS-targeted prevention and treatment were reviewed,aiming to provide reference for clinical practice.

关 键 词：边缘供肝 肝移植 缺血-再灌注损伤(IRI) 氧化应激反应 移植物功能延迟恢复(DGF) 心脏死亡器官捐献(DCD) 活性氧簇(ROS) 体外膜肺氧合(ECMO) 

分 类 号：R617[医药卫生—外科学] R364.5[医药卫生—临床医学]