基于静息态功能磁共振尼古丁依赖者小脑-皮层间功能连接的研究  

Cerebellar-cortical functional connectivity abnormalities in individuals with nicotine dependence

作　　者：张孟哲 高昕宇 杨镇圭 黄荟玉 文萌萌 汪卫建 程敬亮[1] 张勇[1] 许珂[1] ZHANG Mengzhe;GAO Xinyu;YANG Zhengui;HUANG Huiyu;WEN Mengmeng;WANG Weijian;CHENG Jingliang;ZHANG Yong;XU Ke(Department of Magnetic Resonance,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《磁共振成像》2021年第11期42-45,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：河南省医学科技攻关计划联合共建项目(编号:LHGJ20200381)。

摘　　要：目的本研究采用静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)的技术,分析尼古丁依赖者在静息状态下小脑-皮层间功能连接(functional connectivity,FC)的异常改变。材料与方法通过网络平台招募117例尼古丁依赖者和52名年龄和教育程度相匹配的不吸烟志愿者并采集静息状态功能磁共振成像数据。通过回顾性研究,选取双侧小脑CruspⅠ为感兴趣区(region of interest,ROI),计算ROI与全脑的功能连接,探究两组小脑-皮层间功能连接的差异。结果与健康对照组相比,尼古丁依赖者左侧小脑CrusⅠ与默认网络(default mode network,DMN)、运动协调和感觉相关的脑区之间的功能连接显著增高(t=3.56,团块体素≥20)。尼古丁依赖者右侧小脑CrusⅠ与皮层的功能连接较健康对照组无显著差异。结论与健康对照组相比,尼古丁依赖者存在多个小脑-皮层间功能连接的异常,强调了小脑的非运动功能,说明小脑参与尼古丁依赖的神经生物学机制并发挥了作用,并在一定程度上解释了尼古丁依赖者自动吸烟行为和认知、注意的缺陷。Objective:To explore the neuromechanism of nicotine dependence(ND),this study used resting-state functional magnetic resonance imaging(rs-fMRI)to analyze cerebellar-cortical functional connectivity(FC)abnormalities in long-term smokers.Materials and Methods:One hundred and seventeen long-term smokers and 52 non-smoking volunteers matched with age and education were recruited through the network platform.Using rs-fMRI data,we chose bilateral CrusⅠas the region of interest(ROI),and calculated the FC between bilateral CrusⅠand other brain regions to compare the differences of cerebellar-cortical FC between smokers and healthy controls(HCs).Results:Compared with HCs,we found increased FC between the left CrusⅠand brain regions involved in the default mode network(DMN),sensory and motor system in smokers(t=3.56,clusters≥20).The FC between right CrusⅠand cortex in smokers were not significantly different from those in HCs.Conclusions:Long-term smokers showed multiple abnormalities in cerebellar-cortical functional connectivity,and these may be the underlying neuromechanism of nicotine dependence,which are associated with automatized smoking behavior,cognitive and attention deficits.

关 键 词：尼古丁依赖 功能连接 小脑 默认网络 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338.25[医药卫生—诊断学]