遗忘型轻度认知障碍的磁共振成像研究进展  

Magnetic resonance research progress in amnestic mild cognitive impairment

作　　者：李晓陵[1] 蔡丽娜 崔璇 彭彩亮[1,2] 马翠松 刘世平 杨旭 孙旭晨 苑媛 LI Xiaoling;CAI Lina;CUI Xuan;PENG Cailiang;MA Cuisong;LIU Shiping;YANG Xu;SUN Xuchen;YUAN Yuan(Department of CT and MRI,the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Graduate School of Heilongjiang University of traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院CT磁共振科,哈尔滨150040 [2]黑龙江中医药大学研究生院,哈尔滨150040

出　　处：《磁共振成像》2021年第11期94-96,共3页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金面上项目(编号:81973930、82074537);黑龙江省自然科学基金项目(编号:LH2020H103、H2016081);哈尔滨市科技优秀学科带头人项目(编号:2016RAXYJ096);黑龙江中医药大学科研基金(编号:2019MS03)。

摘　　要：轻度认知障碍(mild cognitive impairment,MCI)是正常衰老过程与阿尔茨海默病(Alzheimer disease,AD)之间的过渡阶段,分为遗忘型MCI(amnestic MCI,aMCI)和非遗忘型MCI,前者以记忆损伤为主,被认为是AD的前期。aMCI临床亚型包括单域(single domain,SD)和多域(multi domain,MD),不同的亚型进展为AD的可能性不同。目前,AD的病因和发病机制尚不清楚,没有确切的治愈方法。因此,对aMCI进行早期诊断、干预和治疗,延缓其向AD的进展具有重要意义。近年来,磁共振成像(magnetic resonance imaging,MRI)结合不同的分析方法被应用于aMCI机制的研究,可以客观、间接地反映异常的大脑结构和功能活动,为解释其机制提供一定的线索。作者回顾了aMCI的MRI研究进展。Alzheimer disease(AD)is a progressive age-related neurodegenerative disease.Mild cognitive impairment(MCI)is a transitional stage between the normal aging process and AD.It is divided into amnestic MCI(aMCI)and non-amnestic MCI.The former is mainly memory impairment,which is considered to be the early stage of AD.The clinical subtypes of aMCI include single-domain(SD)and multi-domain(MD).Different subtypes have different possibilities to progress to AD.At present,the etiology and pathogenesis of AD are unclear,and there is no effective cure.Therefore,early diagnosis,intervention and treatment of aMCI and delay its progression to AD are of great significance.In recent years,magnetic resonance imaging combined with different analysis methods have been applied to the study of aMCI mechanism,which can objectively and indirectly reflect the abnormality of brain structure and functional activity,and provide certain clues for explaining its mechanism.Therefore,this article reviews the progress of aMCI magnetic resonance imaging studies.

关 键 词：结构磁共振成像 功能磁共振成像 遗忘型轻度认知障碍 阿尔茨海默病 

分 类 号：R445.2[医药卫生—影像医学与核医学] R749.1[医药卫生—诊断学]