复方玄驹胶囊联合来曲唑治疗排卵障碍性不孕症的疗效及对患者激素水平的影响研究  

Study on the therapeutic effect of compound xuanju capsule combined with letrozole on ovulatory dysfunction infertility and its influence on hormone levels

作　　者：张芳华 刘国桥 ZHANG Fanghua;LIU Guoqiao(Department of Reproductive Medicine,Maternal and Child Health Hospital of Xiaogan in Hubei Province,Xiaogan 432000,China;Department of Pediatrics,Maternal and Child Health Hospital of Xiaogan in Hubei Province,Xiaogan 432000,China)

机构地区：[1]湖北省孝感市妇幼保健院生殖医学科,湖北孝感432000 [2]湖北省孝感市妇幼保健院儿科,湖北孝感432000

出　　处：《中国现代医生》2021年第32期86-89,共4页China Modern Doctor

摘　　要：目的探讨排卵障碍性不孕症应用复方玄驹胶囊、来曲唑联合治疗的效果及其治疗前后激素水平的变化。方法纳入2019年1月至2020年6月本院收治的112例排卵障碍性不孕症患者进行研究,按随机排列法分为对照组56例,于月经周期开始第5天予来曲唑2.5 mg/次,1次/d口服,连续用药5 d;治疗组56例,在此基础上予复方玄驹胶囊3粒/次,3次/d口服。两组均在治疗期间使用B超监测卵泡发育情况,B超显示优势卵泡直径≥18 mm时,则予注射用绒促性素10000 U肌内注射,注射后24~36 h内指导同房。两组均治疗3个月经周期,观察用药前(就诊时)、用药后(治疗3个月经周期末)主卵泡直径变化、子宫内膜厚度变化、血清孕酮(Progesterone,P)、雌二醇(Estradiol,E_(2))、黄体生成素(Luteinizing hormone,LH)、卵泡刺激素(Follicle-stimulating hormone,FSH)水平变化及用药期间不良反应发生情况,完成对疗效及安全性的评价。结果用药后,治疗组主卵泡直径大于用药前,且大于对照组,差异有统计学意义(P<0.05);用药后,治疗组子宫内膜厚度大于用药前,且大于对照组,差异有统计学意义(P<0.05);用药后,两组血清P、E_(2)、LH、FSH水平均高于用药前,且高于对照组,差异有统计学意义(P<0.05);用药期间,两组均未见明显的皮疹、恶心、呕吐等不良反应。结论复方玄驹胶囊联合来曲唑治疗能够促进卵泡的发育及子宫内膜的增生,调节激素水平,同时还不会引起明显的不良反应,应用于排卵障碍性不孕症中安全有效。Objective To explore the effect of compound xuanju capsule combined with letrozole on ovulatory dysfunction infertility and the changes of hormone levels before and after treatment.Methods A total of 112 patients with ovulatory dysfunction infertility admitted to our hospital from January 2019 to June 2020 were enrolled in this study.They were randomly divided into the control group(n=56)treated with letrozole 2.5 mg/time,once a day,orally for five consecutive days on the 5th day after the start of the menstrual cycle and the treatment group(n=56)treated with Compound xuanju capsules orally three capsules/time,three times a day,based on the control group.In both groups,follicular development was monitored using B ultrasound during treatment.When B ultrasound showed that the diameter of the dominant follicle was≥18 mm,10000 units of Chorionic Gonadotrophin for Injection were intramuscularly injected.The patients were guided to perform sexual intercourse within 24 to 36 hours after injection.Both groups were treated for three menstrual cycles.The changes in the diameter of the main follicle,endometrial thickness,serum progesterone(P),estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)levels before(at presentation)and after treatment(at the end of 3 menstrual cycles)and the occurrence of adverse reactions during treatment were observed.The evaluation of efficacy and safety was completed.Results After treatment,the diameter of the main follicle in the treatment group was greater than that before treatment and in the control group,and the difference was statistically significant(P<0.05).After treatment,the endometrial thickness in the treatment group was greater than that before treatment and in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum P,E2,LH,FSH levels in the two groups were higher than those before treatment,and higher than those in the control group.The difference was statistically significant(P<0.05).During treatment,the two gro

关 键 词：激素 复方玄驹胶囊 子宫内膜厚度 不良反应 来曲唑 排卵障碍性不孕症 

分 类 号：R711.6[医药卫生—妇产科学]