中风回春丸辅助治疗对急性脑梗死患者临床疗效、氧化应激和炎症因子水平的影响  

Effects of Zhongfeng Huichun Pill on Clinical Efficacy,Oxidative Stress and Inflammatory Factors Levels in Patients with Acute Cerebral Infarction

作　　者：常利[1] 王龙[2] 李合华[1] CHANG Li;WANG Long;LI He-hua(Department of Neurology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China;Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 237000,China)

机构地区：[1]新乡医学院第一附属医院神经内科,新乡453100 [2]安徽医科大学第一附属医院神经内科,合肥237000

出　　处：《中国合理用药探索》2021年第12期57-61,共5页Chinese Journal of Rational Drug Use

基　　金：河南省医学科技攻关计划普通项目(201702127)。

摘　　要：目的:探讨中风回春丸辅助治疗对急性脑梗死(ACI)患者临床疗效、氧化应激和炎症因子水平的影响。方法:选择2019年1~10月就诊于本院神经内科的84例ACI患者作为研究对象,按照入院时间和治疗方式随机分为对照组和观察组,各42例。对照组采用常规治疗,观察组在对照组基础上给予中风回春丸治疗。比较两组临床疗效;观察两组治疗前和治疗后氧化应激[超氧化物歧化酶(SOD)、丙二醛(MDA)]、炎症因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和超敏C反应蛋白(hs-CRP)]水平的变化;记录两组治疗期间不良反应发生情况。结果:观察组总有效率(92.86%)高于对照组(76.19%,P<0.05)。治疗后,两组SOD、MDA、IL-6、TNF-α、hs-CRP水平优于治疗前,且观察组优于对照组(P<0.05)。治疗期间,两组不良反应总发生率比较无统计学差异(P>0.05)。结论:中风回春丸辅助治疗ACI,可提高临床疗效,且安全性较高,能有效降低机体氧化应激水平和炎症因子水平。Objective:To explore the effects of Zhongfeng Huichun pill on clinical efficacy,oxidative stress and inflammatory factors levels in patients with acute cerebral infarction(ACI).Methods:84 patients with ACI in the department of neurology of our hospital from January 2019 to October 2019 were selected as research subjects,and they were randomly divided into control group and observation group according to admission time and treatment methods,with 42 cases in each group.The control group was treated with routine treatment,and the observation group was treated with Zhongfeng Huichun pill on the basis of the control group.The clinical efficacy of the two groups was compared.The changes of oxidative stress[superoxide dismutase(SOD),malondialdehyde(MDA)],inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitivity C reactive protein(hs-CRP)]levels between the two groups before and after treatment were observed.The adverse reaction of the two groups during treatment was recorded.Results:The total effective rate of the observation group(92.86%)was higher than that of the control group(76.19%,P<0.05).After treatment,the serum levels of SOD,MDA,IL-6,TNF-αand hs-CRP in the two groups were better than those before treatment,and observation group was better than the control group(P<0.05).During treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Zhongfeng Huichun pill as an adjuvant therapy for ACI can improve the clinical efficacy with higher safety.It can also effectively reduce the levels of oxidative stress and inflammatory factors.

关 键 词：急性脑梗死 中风回春丸 临床疗效 氧化应激 炎症因子 不良反应 

分 类 号：R972[医药卫生—药品]