吸入型糖皮质激素治疗持续性哮喘儿童的临床疗效  

Study on Drug Dependence of Inhaled Corticosteroids in the Treatment of Persistent Asthma in Children

作　　者：王文娟 段励夫 WANG Wenjuan;DUAN Lifu(Department of Respiratory Medicine,Shengjing Geriatric Hospital,Shenyang 110000,Liaoning,China)

机构地区：[1]辽宁中置盛京老年病医院呼吸内科,辽宁沈阳110000

出　　处：《中国药物滥用防治杂志》2021年第6期868-870,881,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨吸入型糖皮质激素治疗持续性哮喘儿童的临床疗效。方法:选取2016年6月—2018年6月在该院接受治疗的100例哮喘儿童作为研究对象,按照随机数字表法分为试验组(n=60)和对照组(n=40)。对照组给予常规治疗,试验组给予吸入型糖皮质激素治疗,比较两组身高、体质量、骨代谢指标、血清指标。结果:两组身高、体质量、血钙、血磷、碱性磷酸酶、尿钙/尿肌酐、IGF-1、IGFBP-3、LEP、BGP、CBCL评分比较,差异均无统计学意义(P>0.05);试验组C-ACT评分高于对照组,差异有统计学意义(P<0.05)。结论:常规治疗与持续吸入型糖皮质激素治疗均可改善持续性哮喘患儿临床症状及血清学指标,且不会影响儿童的生长发育,但吸入型糖皮质激素治疗在疾病控制方面具有优势。Objective:To investigate the clinical efficacy of inhaled corticosteroids in the treatment of children with persistent asthma.Methods:A total of 100 children with asthma who were treated in our hospital from June 2016 to June 2018 were selected as the research objects and randomly divided into the experimental group(n=60)and the control group(n=40).The control group was given routine treatment,and the experimental group was given inhaled corticosteroids.The height,weight,bone metabolism indexes and serum indexes were compared between the two groups.Results:There was no significant difference in height,weight,serum calcium,serum phosphorus,alkaline phosphatase,urinary calcium/urinary creatinine,IGF-1,IGFBP-3,LEP,BGP and CBCL scores between the two groups(P>0.05).The C-ACT score of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Both conventional therapy and continuous inhaled glucocorticoid therapy can improve the clinical symptoms and serological indexes of children with persistent asthma,and do not affect the growth and development of children,but inhaled glucocorticoid therapy has advantages in disease control.

关 键 词：吸入型糖皮质激素 持续性哮喘 药物依赖 生长发育 儿童 

分 类 号：R725.6[医药卫生—儿科]