柴胡疏肝散联合富马酸替诺福韦二吡呋酯治疗肝郁气滞型慢性乙型肝炎临床观察  

Clinical Observation on Chaihu Shugan Powder Combined with Tenofovir Fumarate in Treating Chronic Hepatitis B with Liver Depression and Qi Stagnation

作　　者：张金付[1] ZHANG Jinfu(Department of Liver Disease,Sanming Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Fujian Province,Sanming 365001,China)

机构地区：[1]福建中医药大学附属三明中西医结合医院肝病科,福建三明365001

出　　处：《中国中医药现代远程教育》2021年第24期121-123,共3页Chinese Medicine Modern Distance Education of China

基　　金：福建省三明市科学技术局科研课题【No.2019-S-48】。

摘　　要：目的观察柴胡疏肝散联合富马酸替诺福韦二吡呋酯对肝郁气滞型慢性乙型肝炎(Chronic hepatitis B,CHB)的疗效。方法选取2019年6月—2020年5月在福建中医药大学附属三明中西医结合医院肝病科病房收治的60例肝郁气滞型CHB患者,随机平均分为2组,对照组予以富马酸替诺福韦二吡呋酯及保肝、降酶治疗,治疗组在对照组的基础上予以柴胡疏肝散治疗。治疗3个月后观察2组患者中医证候评分、总有效率、肝功能、血清病毒载量、肝脏硬度等情况。结果治疗后治疗组中医证候评分、肝功能指标、肝脏硬度均低于对照组(P<0.05),治疗组总有效率高于对照组(P<0.05)。2组HBV-DNA转阴率比较,差异无统计学意义(P>0.05)。结论柴胡疏肝散联合富马酸替诺福韦二吡呋酯在改善肝郁气滞型CHB患者中医证候、肝功能,降低肝脏硬度等方面优于单用富马酸替诺福韦二吡呋酯治疗。Objective To observe the effect of Chaihu Shugan powder combined with tenofovir fumarate on chronic hepatitis B with liver depression and qi stagnation.Methods 60 cases of chronic hepatitis B patients with liver depression and qi stagnation type in Sanming Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Fujian University of Traditional Chinese Medicine from June 2019 to May 2020 were randomly divided into 2 groups.The control group was treated with tenofovir fumarate and hepatoprotective and enzyme-lowering treatment.The treatment group was treated with Chaihu Shugan powder on the basis of the control group.After 3 months of treatment,observe the two groups of patients TCM syndrome score,total effective rate,liver function,serum viral load,liver stiffness,etc.Results After treatment,the TCM syndrome score,liver function index,serum viral load,and liver stiffness of the treatment group were lower than those of the control group(P<0.05),and the total effective rate of the treatment group was higher than that of the control group(P<0.05).The negative conversion rate of the DNA of hepatitis b virus(HBV-DNA)were observed in two groups.Conclusion Chaihu Shugan powder combined with tenofovir fumarate is better than single-use tenofoate fumarate in improving TCM syndromes,liver function,reducing liver stiffness in patients with liver depression and stagnation type CHB.

关 键 词：胁痛 慢性乙型肝炎 柴胡疏肝散 富马酸替诺福韦二吡呋酯 肝郁气滞 中西医结合疗法 

分 类 号：R512.62[医药卫生—内科学]