Effect of Songlingxuemaikang(松龄血脉康) on mild essential hypertension in patients: a randomized parallel-controlled study  

作　　者：ZHU Guohua SUN Xipeng DING Cuntao ZHAO Huan LI Jing HUA Qi 

机构地区：[1]Department of Geriatric,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China

出　　处：《Journal of Traditional Chinese Medicine》2021年第5期799-805,共7页中医杂志（英文版）

基　　金：Correspondence to:HUA Qi,Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing 100053,[e-mail],Telephone:[phone]。

摘　　要：OBJECTIVE:To evaluate the effect of songlingxuemaikang(松龄血脉康,SLXMK)on mild essential hypertension in patients in terms of endothelial function.METHODS:We enrolled 90 patients with mild essential hypertension in Xuanwu Hospital from January 2016 to December 2016.To evaluate the effects of SLXMK,the 90 patients were randomly assigned at a 2∶1 ratio into 2 groups:the SLXMK group(500 mg per capsule,4500 mg/d,n=60)and the losartan potassium group(50 mg per table,50 mg/d,n=30).The total study period was 12 weeks,and the changes of blood pressure,laboratory test and endothelium function were compared between two groups.RESULTS:After 12 weeks of treatment with SLXMK,blood pressure(BP)and plasma lipid levels significantly improved(P<0.05).Meanwhile,the reactive hyperemia index(RHI)increased in the SLXMK group(P<0.05).The results of multivariate logisticregression analyses examining the association of selected variables with showed that high level of oxidized low density lipoprotein(ox-LDL)was positively associated with endothelial dysfunction.CONCLUSION:SLXMK not only effectively decreased BP and plasma lipid levels,but also reduced ox-LDL and RHI in patients with mild essential hypertension.And SLXMK might improve endothelial function through decreasing the circulating ox-LDL.

关 键 词：essential hypertension endothelial cells lipoproteins LDL HYPEREMIA randomized controlled trial 

分 类 号：R259[医药卫生—中西医结合]