丙泊酚的奖赏效应机制研究进展  

Progress in the study of the mechanisms in propofol s rewarding effect

作　　者：唐其 吴愚 万琪 曾俊伟 TANG Qi;WU Yu;WAN Qi;ZENG Junwei(Department of Physiology,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学生理学教研室,遵义市563000

出　　处：《临床麻醉学杂志》2021年第11期1217-1220,共4页Journal of Clinical Anesthesiology

基　　金：国家自然科学基金资助项目(31860291);贵州省教育厅创新群体重大研究项目(黔教合KY字[2018]025)。

摘　　要：丙泊酚是临床上广泛使用的短效静脉麻醉药,不仅用于麻醉诱导和维持,也用于重症监护室患者的镇静治疗。越来越多的研究表明丙泊酚可诱发奖赏效应的产生,这有可能导致丙泊酚的成瘾及滥用。全文从丙泊酚的动物模型、临床表现以及神经化学机制这几个方面对丙泊酚的奖赏效应进行论述,这有助于为将来临床使用丙泊酚出现成瘾及滥用提供防治策略或思路。Propofol is a widely used short-acting intravenous anesthetic agent in medical practice that is used for induction and maintenance of general anesthesia as well as commonly applied for sedation in intensive care unit.More recent studies have shown that propofol s rewarding effect and the potential for addiction and abuse.The review summarizes the relevant experimental animal data,clinical observations and the possible neurochemical mechanism for propofol s rewarding effect.It will be helpful to provide reference for prevention and treatment for propofol addiction and abuse.

关 键 词：丙泊酚 静脉麻醉药 奖赏效应 成瘾 

分 类 号：R614[医药卫生—麻醉学]