AMPK在心肌纤维化相关疾病中的作用及机制研究进展  

Research progress on the role and mechanism of AMPK in myocardial fibrosis-related diseases

作　　者：李晨霏 樊迪 杨政[1] 唐其柱[1] Li Chen-Fei;Fan Di;Yang Zheng;Tang Qi-Zhu(Department of Cardiology,Renmin Hospital of Wuhan University/Hubei Key Laboratory of Metabolic and Chronic Diseases,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心血管内科/代谢与相关慢病湖北省重点实验室,武汉430060

出　　处：《解放军医学杂志》2021年第12期1239-1244,共6页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81900219,81530012,81800216)。

摘　　要：心肌纤维化是各种心血管疾病进展至心力衰竭的共同病理过程,多条信号通路共同参与了心肌纤维化的发生发展。腺苷酸活化蛋白激酶(AMPK)是一种在人体内广泛分布的三聚体复合物,被称为能量开关,涉及体内多种代谢反应的调控及信号通路的调节。AMPK与心肌纤维化相关信号通路网络相互影响,共同介导了心肌纤维化复杂的病理生理过程。干预AMPK信号通路为心肌纤维化的防治提供了一个新的思路。该文综述了AMPK在多种心肌纤维化相关疾病中的作用及可能机制,进一步探讨了其与几种信号通路的相互影响,并针对三种临床常用药物与AMPK的可能关系进行讨论,旨在加深对AMPK在心肌纤维化中作用的认识及其应用于临床治疗的可能性。Myocardial fibrosis is a common pathological process from various cardiovascular diseases to heart failure,and multiple signal pathways are jointly involved in the development and progression of myocardial fibrosis.AMP-activated protein kinase(AMPK)is a trimer complex widely distributed in human body,which is a central regulator of energy homeostasis involving the regulation of various metabolic responses and signaling pathways in vivo.AMPK interacts with the network of signal pathways related to myocardial fibrosis and jointly mediates the complex pathophysiological changes of myocardial fibrosis.Intervention of AMPK signal pathway provides a new therapeutic idea for the prevention and treatment of myocardial fibrosis.This paper summarizes the role and possible mechanisms of AMPK in different diseases related to cardiac fibrosis.The mutual effects of AMPK in several signaling pathways is also discussed;then further talks about the potential correlations between three kinds of commonly used clinical drugs and AMPK aiming to provide a new idea for the clinical treatment of myocardial fibrosis.

关 键 词：心肌纤维化 腺苷酸活化蛋白激酶 信号通路 药物治疗 

分 类 号：R541.4[医药卫生—心血管疾病]