急性心肌梗死患者外周血TLR4、HPSE表达及其临床意义  

Expression of TLR4 and HPSE in Peripheral Blood of Patients with Acute Myocardial Infarction and Their Clinical Significance

作　　者：陆小群 孙杰 丁佳成 LU Xiaoqun;SUN Jie;DING Jiacheng(Changzhou No.7 People’s Hospital,Changzhou 213011,China;不详)

机构地区：[1]常州市第七人民医院,江苏常州213011

出　　处：《中外医学研究》2021年第35期83-86,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨急性心肌梗死(AMI)患者外周血Toll样受体4(TLR4)、乙酰肝素酶(HPSE)的表达及其临床意义。方法:选取2019年1月-2021年1月本院收治的60例急性心肌梗死(AMI)患者纳入AMI组,选取同期于本院接受治疗的不稳定型心绞痛(UAP)患者60例作为UAP组,另选取同期于本院因出现胸痛不适,经一系列检查后排除冠心病患者60例作为对照组。比较三组外周血TLR4、HPSE水平及冠状动脉病变程度(Gensini积分),并采用Pearson相关系数对上述指标进行相关性分析。结果:AMI组TLR4、HPSE水平及Gensini积分均>UAP组>对照组,三组间两两比较,差异均有统计学意义(P<0.05);经Spearman相关性检验结果显示,AMI患者外周血TLR4、HPSE水平均与Gensini积分呈正相关(r>0,P<0.05)。结论:AMI患者外周血TLR4、HPSE呈高表达,且与冠状动脉病变程度密切相关,可为临床AMI患者病情评估提供参考依据。Objective:To investigate the expression and clinical significance of Toll-like receptor 4 (TLR4) and heparanase (HPSE) in patients with AMI.Method:A total of 60 patients with acute myocardial infarction (AMI) admitted to our hospital from January 2019 to January 2021 were selected as the AMI group.A total of 60 patients with unstable angina pectoris (UAP) who received treatment in our hospital during the same period were selected as the UAP group,and another 60 patients with coronary heart disease who were excluded after a series of examinations due to chest pain and discomfort in our hospital during the same period were selected as the control group.The levels of TLR4 and HPSE in peripheral blood and the degree of coronary artery lesions (Gensini score) were compared among the three groups,and Pearson correlation coefficient was used to analyze the correlation between these indexes.Result:The levels of TLR4,HPSE and Gensini scores in AMI group were >UAP group >control group,and the differences were statistically significant (P<0.05).Spearman correlation test showed that TLR4 and HPSE levels in peripheral blood of patients with AMI were positively correlated with Gensini score (r>0,P<0.05).Conclusion:TLR4 and HPSE are highly expressed in peripheral blood of patients with AMI,which are closely related to the severity of coronary artery disease,and can provide objective evaluation basis for clinical assessment of patients with AMI.

关 键 词：急性心肌梗死 心功能 TOLL样受体4 乙酰肝素酶 预测 

分 类 号：R542.22[医药卫生—心血管疾病]