宫腔灌注人绒毛膜促性腺激素对薄型子宫内膜冻融周期临床结局的影响  

Effect of Intrauterine Perfusion of Human Chorionic Gonadotropin on the Clinical Outcome of Thin Endometrial Freeze-thaw Cycle

作　　者：张文权[1] 黄开淑[1] 陈程 唐玢[1] 张玲[1] 廖丽雅 卜雯雯 ZHANG Wenquan;HUANG Kaishu;CHEN Cheng;TANG Bin;ZHANG Ling;LIAO Liya;BU Wenwen(The First People’s Hospital of Changde City,Changde 415003,China;不详)

机构地区：[1]常德市第一人民医院,湖南常德415003

出　　处：《中外医学研究》2021年第34期9-12,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：湖南省科技厅创新引导项目(2017SK51307)。

摘　　要：目的:探讨宫腔灌注人绒毛膜促性腺激素(hCG)对薄型子宫内膜冻融周期临床结局的影响。方法:回顾性选取2018年1月-2020年12月湖南省常德市第一人民医院生殖医学中心接受冻融胚胎移植(FET)105例薄型子宫内膜患者的临床资料,根据是否接受宫腔灌注hCG分为研究组(55例,宫腔灌注hCG 500 U)和对照组(50例,未行宫腔灌注)。分析比较两组的黄体转化日及移植日子宫内膜厚度、临床妊娠率、胚胎种植率、多胎妊娠率、异位妊娠率、早期流产率。结果:两组黄体转化日及移植日子宫内膜厚度、多胎妊娠率、异位妊娠率、早期流产率比较差异均无统计学意义(P>0.05),研究组临床妊娠率、胚胎种植率显著高于对照组,差异均有统计学意义(P<0.05)。结论:宫腔灌注hCG能提高薄型子宫内膜患者FET周期的临床妊娠率和胚胎种植率,改善薄型子宫内膜患者冻融周期的临床结局。Objective:To explore the effect of intrauterine perfusion of human chorionic gonadotropin (hCG) on the clinical outcome of thin endometrial freeze-thaw cycle.Method:The clinical data of 105 patients with thin endometrium who received freezing-thawing embryo transfer (FET) in the Reproduction Medicine Center of the First People’s Hospital of Changde City,Hunan Province from January 2018 to December 2020 were retrospectively selected and divided into the study group (55 cases,intrauterine perfusion with hCG 500 U) and the control group (50 cases,no intrauterine perfusion was performed) according to whether or not they received intrauterine hCG perfusion.The endometrial thickness on luteal transformation day and transplantation day,clinical pregnancy rate,embryo implantation rate,multiple pregnancy rate,ectopic pregnancy rate and early abortion rate between the two groups were analyzed and compared.Result:There were no significant differences in endometrial thickness on luteal transformation day and transplantation day,multiple pregnancy rate,ectopic pregnancy rate and early abortion rate between the two groups (P>0.05).The clinical pregnancy rate and embryo implantation rate in the study group were significantly higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Intrauterine perfusion of hCG can improve the clinical pregnancy rate and embryo implantation rate in patients with thin endometrium in FET cycle and improve the clinical outcome of patients with thin endometrium.

关 键 词：薄型子宫内膜 人绒毛膜促性腺激素 冻融胚胎移植 临床结局 

分 类 号：R714.8[医药卫生—妇产科学]