伊伐布雷定联合重组脑利钠肽对急性左心衰患者的影响  

Effect of Ivabradine Combined with Recombinant Brain Natriuretic Peptide on Patients with Acute Left Heart Failure

作　　者：林锐[1] 陈扬波[1] 林涌坚 周浩粤[1] 黄伟鹏[1] 邝鸿生[1] LIN Rui;CHEN Yangbo;LIN Yongjian;ZHOU Haoyue;HUANG Weipeng;KUANG Hongsheng(Jieyang People’s Hospital,Jieyang 522000,China;不详)

机构地区：[1]揭阳市人民医院,广东揭阳522000

出　　处：《中外医学研究》2021年第34期33-36,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：2019年度揭阳市科技创新项目(190821152353562)。

摘　　要：目的:探讨伊伐布雷定联合重组脑利钠肽对急性左心衰患者的影响。方法:选取本院2019年7月-2021年6月收治的80例急性左心衰患者,按随机数字表法分为对照组和观察组,各40例。两组患者均给予常规治疗,对照组患者在常规治疗的基础上给予重组脑利钠肽,观察组给予重组脑利钠肽联合伊伐布雷定片治疗,比较两组患者临床疗效,治疗前、治疗后1个月的心功能指标,治疗前、治疗后3 d的N末端B型脑钠肽前体水平、血流动力学指标。结果:观察组总有效率高于对照组(P<0.05)。与治疗前相比,治疗后1个月两组患者左心室收缩末期内径、左心室舒张末期内径均下降,且观察组均低于对照组(P<0.05),左心室射血分数升高,且观察组高于对照组(P<0.05)。与治疗前相比,治疗后3 d两组患者N末端B型脑钠肽前体水平、呼吸频率、心率、血压均下降,观察组均低于对照组(P<0.05),血氧饱和度升高,观察组高于对照组(P<0.05)。结论:伊伐布雷定联合重组脑利钠肽可有效改善急性左心衰患者临床症状,控制心肌重塑,改善心肌细胞功能,稳定血流动力学水平。Objective:To explore the effect of Ivabradine combined with Recombinant Brain Natriuretic Peptide on patients with acute left heart failure.Method:A total of 80 patients with acute left heart failure treated in our hospital from July 2019 to June 2021 were selected and divided into the control group and observation group according to the random number table method,with 40 cases in each group.Both groups were given routine treatment,the patients in the control group were given Recombinant Brain Natriuretic Peptide on the basis of routine treatment,the observation group was given Recombinant Brain Natriuretic Peptide combined with Ivabradine Tablets.The clinical efficacy,cardiac function indexes before and 1 month after treatment,N-terminal B-type brain natriuretic peptide precursor level and hemodynamic indexes before and 3 d after treatment of the two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group (P<0.05).Compared with before treatment,1 month after treatment,the left ventricular end systolic diameter and left ventricular end diastolic diameter of the two groups decreased,the observation group was lower than that of the control group (P<0.05),the left ventricular ejection fraction increased,and the observation group were lower than the control group (P<0.05),left ventricular ejection fraction increased,and the observation group was higher than the control group (P<0.05).Compared with before treatment,the level of N-terminal B-type brain natriuretic peptide precursor,respiratory rate,heart rate and blood pressure in the two groups decreased 3 d after treatment,and those in the observation group were lower than those in the control group (P<0.05),and the blood oxygen saturation increased,which in the observation group was higher than that in the control group (P<0.05).Conclusion:Ivabradine combined with Recombinant Brain Natriuretic Peptide can effectively improve clinical symptoms,control myocardial remodeling,improve cardiomyocyte function

关 键 词：急性左心衰 伊伐布雷定 重组脑利钠肽 心肌细胞 血流动力学 

分 类 号：R541.6[医药卫生—心血管疾病]