马骨续筋胶囊联合微创经皮椎弓根螺钉固定术对胸腰椎压缩性骨折愈合的影响  

Effect of Magu Xujin Capsules Combined with Minimally Invasive Percutaneous Pedicle Screw Fixation on Fracture Healing in Patients with Thoracolumbar Vertebral Compression Fracture

作　　者：周宝柱 刘道阔[1] 张鹏 槐恒达 赵娜 胡思斌[1] ZHOU Baozhu;LIU Daokuo;ZHANG Peng;HUAI Hengda;ZHAO Na;HU Sibin(Cangzhou Hospital of Integrated TCM-WM-Hebei,Cangzhou,Hebei,China 061000)

机构地区：[1]河北省沧州中西医结合医院,河北沧州061000

出　　处：《中国药业》2022年第1期95-98,共4页China Pharmaceuticals

基　　金：河北省中医药管理局科研计划项目[2020500]。

摘　　要：目的探讨马骨续筋胶囊联合微创经皮椎弓根螺钉固定术对胸腰椎压缩性骨折患者骨折愈合的影响。方法选取医院2018年1月至2020年1月收治的胸腰椎压缩性骨折患者96例,随机分为观察组和对照组,各48例。两组患者均予微创经皮椎弓根螺钉固定术治疗,观察组患者加用马骨续筋胶囊,连续用药3个月。结果观察组术后失访1例,对照组术后失访2例,均予以剔除。术后,观察组患者的骨折线消失时间、骨痂形成时间、骨折完全愈合时间均显著短于对照组(P<0.05);术后的视觉模拟评分法(VAS)评分均显著低于对照组(P<0.05);术后观察组患者的伤椎前缘高度、伤椎后缘高度均显著高于对照组,Cobbs角显著低于对照组(P<0.05);术后,观察组患者的血清碱性磷酸酶、Ⅰ型前胶原氨基末端前肽、骨钙素水平均显著高于对照组(P<0.05),血管内皮生长因子、转化生长因子β_(1)、成纤维细胞生长因子水平均显著高于对照组(P<0.05);治疗期间,观察组和对照组不良反应发生率相当(14.89%比8.70%,P>0.05)。结论马骨续筋胶囊联合微创经皮椎弓根螺钉固定术治疗胸腰椎压缩性骨折疗效较好,能促进骨折 愈合,恢复伤椎的正常生理结构,降低术后疼痛,改善骨代谢,提高各项生长因子水平,且治疗安全性良好。Objective To investigate the effect of Magu Xujin Capsules combined with minimally invasive percutaneous pedicle screw fixation on fracture healing in patients with thoracolumbar vertebral compression fracture.Methods A total of 96 patients with thoracolumbar vertebral compression fractures admitted to the hospital from January 2018 to January 2020 were selected and randomly divided into the observation group and the control group,with 48 cases in each group.The patients in the two groups were treated with minimally invasive percutaneous pedicle screw fixation,on this basis,the patients in the observation group were treated with Magu Xujin Capsules.Both groups were continously treated for three months.Results After the operation,one case was lost to follow-up in the observation group,two cases were lost to follow-up in the control group,and the above patients were excluded.After operation,the fracture line disappearance time,callus formation time,fracture healing time in the observation group were significantly shorter than those in the control group(P<0.05),and the visual analogue scale(VAS)score in the observation group was significantly lower than that in the control group(P<0.05).After operation,the anterior body height and posterior body height of the injured vertebra in the observation group were significantly higher than those in the control group,while the Cobbs angle in the observation group was significantly lower than that in the control group(P<0.05).After operation,the levels of serum alkaline phosphatase(ALP),typeⅠprocollagen amino-terminal propeptide(PINP)and osteocalcin(BPG)in the observation group were significantly higher than those in the control group(P<0.05).The levels of vascular endothelial growth factor(VEGF),transforming growth factor-β_(1)(TGF-β_(1))and fibroblast growth factor(FGF)in the observation group were significantly higher than those in the control group(P<0.05).During the treatment,the incidence of adverse reactions in the observation group was similar to that in the contro

关 键 词：胸腰椎压缩性骨折 马骨续筋胶囊 经皮椎弓根螺钉固定术 骨折愈合 骨代谢 生长因子 

分 类 号：R932[医药卫生—生药学] R285.6[医药卫生—药学]