冠心病患者血清D-二聚体、肌红蛋白表达与冠状动脉重构的相关性研究  

Correlation between expressions of serum D-dimer and myoglobin and coronary artery remodeling in patients with coronary heart disease

作　　者：马乔炎[1] 曹倩[1] 张平[1] 张建秀[1] 王立中 Ma Qiaoyan;Cao Qian;Zhang Ping;Zhang Jianxiu;Wang Lizhong(Center of Heart Rehabilitation,Beijing Rehabilitation Hospital,Capital Medical University,Beijing 100144,China;不详)

机构地区：[1]首都医科大学附属北京康复医院心脏康复中心,北京100144

出　　处：《中国循证心血管医学杂志》2021年第12期1507-1509,1512,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探究冠状动脉粥样硬化性心脏病(冠心病)患者血清D-二聚体、肌红蛋白表达与冠状动脉(冠脉)重构的相关性。方法选择2018年4月至2019年12月于首都医科大学附属北京康复医院心脏康复中心收治的186例行冠脉造影检查的患者,按造影结果分为冠心病组123例(确诊为冠心病)和对照组63例(非冠心病者)。冠心病组中又分为:冠脉血管正性重构(血管重构指数RI≥1.05)者51例(正性重构组)和非正性重构(RI<1.05)者72例(非正性重构组)。收集所有受试者的临床资料,测量血管重构指数(RI),检测血清D-二聚体、肌红蛋白水平,采用Spearman法分析血清D-二聚体、肌红蛋白水平与RI的相关性,通过Logistic回归分析影响冠心病患者血管重构的危险因素。结果与非正性重构组比较,正性重构组冠心病患者高血压比例、RI、血清D-二聚体、肌红蛋白及超敏C反应蛋白(hs-CRP)水平均显著升高(P<0.05)。Spearman相关性分析结果显示,冠心病患者血清D-二聚体、肌红蛋白水平均与RI呈正相关(P<0.05)。Logistic回归分析结果显示,高血压、血清D-二聚体、肌红蛋白水平是影响冠心病患者血管重构的独立危险因素(P<0.05)。结论冠心病患者血清D-二聚体、肌红蛋白表达水平升高可能与冠脉正性重构有关,是影响其发生的独立危险因素。Objective To study the correlation between expressions of serum D-dimer(D-D)and myoglobin(Myo)and coronary artery remodeling in patients with coronary heart disease(CHD).Methods The patients(n=186)received routine coronary angiography examination were chosen from Center of Heart Rehabilitation in Beijing Rehabilitation Hospital affiliated to Capital Medical University from Apr.2018 to Dec.2019,and divided,according to angiography results,into CHD group(n=123)and control group(n=63).CHD group were divided further into positive remodeling subgroup[remodeling index(RI)≥1.05,n=51]and non-positive remodeling subgroup(RI<1.05,n=72).The clinical materials were collected,RI was measured and levels of D-D and Myo were detected in all groups.The correlation between RI and levels of D-D and Myo was analyzed by using Spearman correlation analysis method.The risk factors influencing coronary artery remodeling were analyzed by using Logistic regression analysis in CHD patients.Results The percentage of hypertensive cases,RI and levels of serum D-D,Myo and high sensitivity C-reactive protein(hs-CRP)increased significantly in positive remodeling subgroup compared with non-positive remodeling subgroup(P<0.05).The results of Spearman correlation analysis showed that levels of serum D-D and Myo were positively correlated to RI in CHD patients(P<0.05).The results of Logistic regression analysis showed that hypertension and levels of serum D-D and Myo were independent risk factors influencing coronary artery remodeling in CHD patients(P<0.05).Conclusion The increases of levels of serum D-D and Myo may be related to positive coronary artery remodeling in CHD patients,which are independent risk factors influencing remodeling incidence.

关 键 词：冠心病 D-二聚体 肌红蛋白 冠脉重构 

分 类 号：R541.4[医药卫生—心血管疾病]