NLR、PLR、NT-proBNP联合预测急性冠脉综合征患者急诊PCI后新发房颤的价值  

Value of NLR,PLR and NT-proBNP in predicting new onset atrial fibrillation after emergency PCI in patients with acute coronary syndrome

作　　者：罗勤[1] 李姣 周国忠[1] 黄文军[1] LUO Qin;LI Jiao;ZHOU Guozhong;HUANG Wenjun(Department of Cardiology,Pingxiang People's Hospital,Pingxiang,Jiangxi,China,337000;B-mode Ultrasound Department,Pingxiang People's Hospital,Pingxiang,Jiangxi,China,337000)

机构地区：[1]江西省萍乡市人民医院,江西萍乡337000 [2]萍乡市人民医院B超室,江西萍乡337000

出　　处：《分子诊断与治疗杂志》2021年第12期2051-2055,共5页Journal of Molecular Diagnostics and Therapy

基　　金：萍乡市科技计划项目(2018PY022)。

摘　　要：目的研究中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、氨基末端BNP前体(NT-proBNP)预测急性冠脉综合征(ACS)患者急诊经皮冠状动脉介入术(PCI)后新发房颤(NOAF)的价值。方法选择2019年1月至2020年12月在萍乡市人民医院接受急诊PCI的ACS患者作为研究对象,分为PCI后出现NOAF的NOAF组(n=31)、未出现NOAF的非NOAF组(n=123)。比较两组患者临床资料的差异,采用logistic回归模型分析NOAF的影响因素,采用ROC曲线分析NOAF的预测指标。结果 NOAF组患者入院时的NLR、PLR、低密度脂蛋白胆固醇、心肌肌钙蛋白I、NT-proBNP水平及PCI术中SYNTAX评分、GRACE评分、Gennisi评分均高于非NOAF组,差异有统计学意义(P<0.05);经logistic回归分析,入院时NLR、PLR、NT-proBNP及PCI术中SYNTAX评分、GRACE评分、Gennisi评分是PCI后NOAF的影响因素(P<0.05);经ROC曲线分析,入院时NLR、PLR、NT-proBNP水平对PCI后NOAF具有预测价值(P<0.05)。结论入院时NLR、PLR、NT-proBNP升高是ACS患者PCI后NOAF的影响因素,检测NLR、PLR、NT-proBNP对NOAF具有预测价值。Objective To study the value of neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR)and N-terminal proBNP(NT-proBNP)in predicting new onset atrial fibrillation(NOAF)after emergency percutaneous coronary intervention(PCI)in patients with acute coronary syndrome(ACS). Methods ACS patients who underwent emergency PCI in our hospital from January 2019 to December 2020 were selected as the research object. They were divided into NOAF group with NOAF after PCI(n=31)and non NOAF group without NOAF(n=123). The differences of clinical data between the two groups were compared,the influencing factors of NOAF were analyzed by logistic regression model,and the predictive indexes of NOAF were analyzed by ROC curve. Results The levels of NLR,PLR,low density lipoprotein cholesterol,cardiac troponin I,NT-proBNP,SYNTAX score,GRACE score and Gennisi score in NOAF group were higher than those in non NOAF group(P<0.05). Logistic regression analysis showed that NLR,PLR,NT-proBNP,SYNTAX score,GRACE score and Gennisi score during PCI were the influencing factors of NOAF after PCI(P<0.05). By ROC curve analysis,the levels of NLR,PLR and NT-proBNP at admission had predictive value for NOAF after PCI(P<0.05). Conclusion The increase of NLR,PLR and NT-proBNPat admission is the influencing factor of NOAF in ACS patients after PCI. The detection of NLR,PLR and NTpro BNP has predictive value for NOAF.

关 键 词：急性冠脉综合征 经皮冠状动脉介入术 新发房颤 中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 氨基末端BNP前体 

分 类 号：R541.4[医药卫生—心血管疾病]