CTX-Ⅰ, TRACP, ADAMTS-4 and MMPs-3 expression and their correlation with different syndromes of knee osteoarthritis  

作　　者：Run Jiang Tao Zhang Jun Duan Zhen Mao 

机构地区：[1]Department of Rheumatology,Wuhan Caidian District People's Hospital,Wuhan 430000,China [2]Department of Rehabilitation Pain,Wuhan Caidian District People's Hospital,Wuhan 430000,China

出　　处：《Journal of Hainan Medical University》2021年第23期21-25,共5页海南医学院学报（英文版）

基　　金：Research Project Funding of Health and Family Planning Commission of Wuhan(No.WZ20Q12);Key Program of the National Natural Science Fund of China(No.81590955)。

摘　　要：Objective:To observe the expression of CTX-I(Ⅰcollagen C-terminal foreign body peptide)and TRACP(tartrate-resistant acid phosphatase)in different syndromes of knee osteoarthritis and their correlation with ADAMTS-4(polyproteoglycan enzyme-4)and MMPS-3(matrix metalloproteinase-3).Methods:A total of 98 patients diagnosed with knee osteoarthritis were enrolled from the Rehabilitation Pain Department and Rheumatology Department of Wuhan Caidian District People's Hospital.According to their syndrome types,they were divided into 40 cases of Yang deficiency and cold constipation type,28 cases of qi stagnation and blood stasis type,and 30 cases of kidney jing deficiency type.The contents of bone metabolism indexes,ADAMTS-4 and MMPS-3 in different syndromes of the three groups were compared.Correlation of bone metabolism indexes with ADAMTS-4 and MMPS-3.Results:There were statistically significant differences in the contents of CTX-I,TRACP,ADAMTS-4 and MMPS-3 among three groups with different syndromes(P<0.05).There was a positive correlation between CTX-I,TRACP,ADAMTS-4 and MMPS-3(P<0.05).The syndrome of qi stagnation and blood stasis was positively correlated with TRACP and ADAMTS-4,and negatively correlated with MMPS-3(P<0.05).The renal essence deficiency syndrome was positively correlated with CTX-I,ADAMTS-4 and MMPS-3(P<0.05).Bone metabolic indexes(CTX-I,TRACP)were positively correlated with ADAMTS-4 and MMPS-3(P<0.05).Conclusion:Different syndromes of knee osteoarthritis are correlated with bone metabolism indexes,ADAMTS-4 and MMPS-3,which can provide a certain objective basis for clinical TCM syndrome differentiation and classification。

关 键 词：Knee osteoarthritis TCM syndrome Bone metabolism ADAMTS-4 Correlation study 

分 类 号：R68[医药卫生—骨科学]