中老年人群TyG指数及其结合肥胖指标与高血压前期的关联性研究  

Correlation between TyG and TyG combined obesity index and prehypertension in middle-aged and elderly population

作　　者：罗凌风 张增利[1] LUO Ling-feng;ZHANG Zeng-li(School of Public Health,Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学医学部公共卫生学院,江苏苏州215000

出　　处：《公共卫生与预防医学》2022年第1期58-62,共5页Journal of Public Health and Preventive Medicine

摘　　要：目的探索我国中老年人群中甘油三酸酯葡萄糖指数(Triglyceride Glucose Index,TyG)及其结合肥胖指标与高血压前期的关系,为更好的分级管理高血压前期人群提供辅助措施。方法通过中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)数据库纳入非高血压人群5099名;获得体质指数(Body Mass Index,BMI)、腰围(Waist Circumference,WC)和腰围身高比(Waist to Height Ratio,WtHR)等指标。将TyG指数分别与三者相乘计算TyG-BMI、TyG-WC和TyG-WtHR指数。logistic回归分析探讨TyG指数及其结合肥胖指标作为连续型变量与四分位分类变量与高血压前期的关系。使用Delong法对各个指标值(Area Under the Curve,AUC)进行比较以区分其识别高血压前期的价值。结果logistic回归分析显示,连续型变量TyG、TyG-BMI、TyG-WtHR与高血压前期无显著关联,TyG-WC与高血压前期存在弱相关,其OR值别为1.002(95%CI:1.001~1.003);较高水平的四分位分类变量TyG-BMI、TyG-WC指数与高血压前期存在显著关联,与最低四分位数组Q1相比,TyG-BMI指数Q2-Q4的OR值分别为1.24(95%CI:1.03~1.49)、1.40(95%CI:1.10~1.76)、1.91(95%CI:1.43~2.56);TyG-WC指数Q2-Q4组的OR值分别为1.45(95%CI:1.19~1.75)、1.49(95%CI:1.13~1.95)、2.12(95%CI:1.47~3.07),但TyG-WC与TyG-BMI指数的AUC值比较差异无统计意义(P=0.09)。结论4个新颖指标中,较高水平的TyG-WC、TyG-BMI指数与高血压前期存在正关联,TyG-WC、TyG-BMI相较于TyG、TyG-WtHR指数较有潜力成为中老年人高血压前期个体分级管理中有效指标。Objective To explore the correlation between Triglyceride Glucose Index(TyG)and its combined obesity Index and prehypertension in middle-aged and elderly population in China,and to provide a monitoring tool for better hierarchical management of prehypertension population.Methods A total of 5099 people with non-hypertension were enrolled through the database of the China Health and Retirement Longitudinal Study(CHARLS).Body mass index(BMI),waist circumference(WC)and waist to height ratio(WTHR)were obtained,and TyG-BMI,TyG-WC and TyG-WTHR indexes were calculated by multiplying the TyG index with the three indexes respectively.Logistic regression analysis was used to explore the relationship between TyG index and obesity index and prehypertension.The DeLong method was used to compare the values of Area Under the Curve(AUC)of each index to distinguish their value in identifying prehypertension.Results Compared with the normal blood pressure group,the prehypertension group was older,and the blood pressure was higher.Logistic regression analysis showed that higher levels of TyG-BMI and TyG-WC index were significantly associated with prehypertension.Compared with the lowest quartile array Q1,the OR values of TyG-BMI Q2-Q4 were 1.24(95%CI:1.03-1.49),1.40(95%CI:1.10-1.76)and 1.91(95%CI:1.43-2.56),while the OR values of TyG-WC index Q2-Q4 group were 1.45(95%CI:1.19-1.75),1.49(95%CI:1.13-1.95),and 2.12(95%CI:1.47-3.07),respectively.There was no statistically significant difference in the AUC value between TyG-WC and TyG-BMI(P=0.0998).Conclusion Among the four novel indexes,higher levels of TyG-WC and TyG-BMI are positively correlated with prehypertension.Compared with TyG and TyG-WTHR,TyG-WC and TyG-BMI have the potential to become an effective auxiliary means in the individual hierarchical management of prehypertension in the middle-aged and elderly.

关 键 词：甘油三酸酯葡萄糖指数 肥胖 高血压前期 

分 类 号：R18[医药卫生—流行病学]