肿瘤初次化疗预防恶心呕吐用药合理性分析  

Analysis of Rationality of Drugs Used to Prevent Nausea and Vomiting in Cancer Patients Undergoing Primary Chemotherapy

作　　者：唐慕菲[1] 李园园[1] TANG Mufei;LI Yuanyuan(Department of Pharmacy,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)药学部,南京210006

出　　处：《药学与临床研究》2021年第6期458-461,共4页Pharmaceutical and Clinical Research

基　　金：南京药学会-常州四药医院药学科研基金项目(2019YX028)。

摘　　要：目的:分析肿瘤初次化疗患者预防恶心呕吐(Chemotherapy induced nausea and vomiting,CINV)的用药合理性,促进合理安全用药。方法:收集肿瘤内科2020年9月至2021年2月肿瘤患者初次化疗的病历,对其预防化疗所致恶心呕吐用药进行合理性分析。结果:在纳入的131例病历中,主要不合理现象包括预防用药不足(占30.53%)、药物过度使用(占28.24%)、质子泵抑制剂(Proton Pump Inhibitors,PPIs)使用证据不足(占65.65%)、糖皮质激素种类选择存在问题(占57.25%)、用量不适宜(占24.42%)、用药频次不适宜(占5.34%)以及用药疗程不适宜(占45.03%)。结论:预防CINV用药存在不合理现象。须通过完善并优化医嘱审核,加强用药宣教,加深临床药师自身专业知识积累,以提高预防CINV用药的合理性。Objective:To analyze the rationality of drug use for preventing primary chemotherapy induced nausea and vomiting(CINV)in cancer patients in order to promote their efficacy and safety.Methods:The medical records of patients with primary chemotherapy in the Department of Oncology from September 2020 to February 2021 were collected,and the rationality of drug use for prevention of CINV was analyzed.Results:In 131 cases,the main unreasonable prescriptions included insufficient preventive medication(30.53%),excessive drug use(28.24%),insufficient evidence on the use of proton pump inhibitors(PPIs)(65.65%),wrong selection of glucocorticoids(57.25%),inappropriate dosage of medication(24.42%),inappropriate frequency of medication(5.34%)and inappropriate course of medication(45.03%).Conclusion:There is unreasonable use of drugs to prevent CINV.It is necessary to improve the rationality of CINV prevention by improving and optimizing the audit of doctor's orders,strengthening drug use education and enhancing the accumulation of professional knowledge of clinical pharmacists.

关 键 词：肿瘤 初次化疗 恶心呕吐 预防 合理用药 

分 类 号：R969.3[医药卫生—药理学]