二甲双胍缓释片与速释片治疗2型糖尿病患者临床效果对比分析  

Comparative analysis of the clinical effect of metformin sustained-release tablets and immediate-release tablets in the treatment of type 2 diabetes mellitus

作　　者：周晓燕 ZHOU Xiaoyan(Department of Drug and Equipment,The Fourth People′s Hospital of Zhumadian City,Zhumadian 463000,Henan Province,China)

机构地区：[1]驻马店市第四人民医院药械科,河南省驻马店市463000

出　　处：《内科》2021年第6期754-757,共4页Internal Medicine

基　　金：2018年度河南省医学科技攻关计划联合共建项目(2018020300)。

摘　　要：目的对比分析二甲双胍缓释片、二甲双胍速释片治疗新诊断2型糖尿病(T2DM)患者的临床效果及安全性。方法选取2019年3月至2020年6月本院收治的新诊断T2DM患者98例为研究对象,采用随机数字法分为缓释组和速释组各49例。缓释组患者给予二甲双胍缓释片治疗,速释组患者给予二甲双胍速释片治疗。连续治疗3个月后,比较两组患者的临床疗效;比较两组患者治疗前后血糖、血脂及肠道菌群变化情况;比较两组患者治疗过程中的不良反应发生情况。结果治疗3个月,两组患者的治疗总有效率比较,差异无统计学意义(P>0.05)。治疗前,两组患者的空腹血糖(FBG)和餐后2h血糖(2hPBG)、总胆固醇(TC)及三酰甘油(TG)水平比较,差异无统计学意义(P>0.05);治疗3个月后,两组患者的FBG、2hPBG、TC及TG水平均显著降低(P<0.05),但两组患者的FBG、2hPBG、TC及TG水平比较,差异无统计学意义(P>0.05)。治疗前,两组患者肠道内的双歧杆菌、乳酸杆菌及拟杆菌数量比较,差异无统计学意义(P>0.05);治疗3个月后,两组患者肠道内的双歧杆菌、乳酸杆菌及拟杆菌数量均显著增多(P<0.05),但两组患者肠道内的双歧杆菌、乳酸杆菌及拟杆菌数量比较,差异无统计学意义(P>0.05)。治疗期间,缓释组患者的不良反应发生率(8.16%)明显低于速释组(22.45%),差异有统计学意义(P<0.05)。结论二甲双胍缓释片和速释片治疗均能有效降低T2DM患者的血糖、血脂水平,调节患者肠道菌群,临床疗效相近,但二甲双胍缓释片治疗的不良反应较少,使用更为方便。Objective To comparatively analyze the clinical effect and safety of metformin sustained-release tablets and metformin immediate-release tablets in the treatment of patients with newly diagnosed type 2 diabetes mellitus(T2DM).Methods A total of 98 newly diagnosed T2DM patients admitted to our hospital between March 2019 and June 2020 were selected as the research objects and were divided into sustained-release group and immediate-release group by the random number method,with 49 cases in each group.Patients in the sustained-release group were treated with metformin sustained-release tablets,whereas patients in the immediate-release group were treated with metformin immediate-release tablets.After continuous treatment for 3 months,the clinical efficacy of the two groups was compared.The changes in blood glucose,blood lipid and intestinal floras were compared between the two groups before and after treatment.The occurrence of adverse reactions during treatment was also compared between the two groups.Results After 3 months of treatment,there was no statistically significant difference in the total effective rate of treatment between the two groups(P>0.05).Before treatment,fasting blood glucose(FBG)and 2h postprandial blood glucose(2hPBG),total cholesterol(TC)and triglyceride(TG)levels were not significantly different between the two groups(P>0.05).After 3 months of treatment,the levels of FBG,2hPBG,TC and TG in both groups significantly decreased(P<0.05),but there were no statistically significant differences in FBG,2hPBG,TC and TG between the two groups(P>0.05).Before treatment,there were no statistically significant differences in the number of intestinal bifidobacterium,lactobacilus and bacteroide between the two groups(P>0.05).After 3 months of treatment,the number of intestinal bifidobacterium,lactobacillus and bacteroide in both groups significantly increased(P<0.05),but there were no statistically significant differences in the number of intestinal bifidobacterium,lactobacilus and bacteroide between the two

关 键 词：2型糖尿病 二甲双胍缓释片 二甲双胍速释片 

分 类 号：R587.1[医药卫生—内分泌]