Togni-ⅡReagent Mediated Selective Hydrotrifluoromethylation and Hydrothiolation of Alkenes  

作　　者：Shuang Teng Lingkui Meng Bingbing Xu Guangsheng Tu Peng Wu Zhiwen Liao Yulin Tan Jian Guo Jing Zeng Qian Wan 

机构地区：[1]Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Huazhong University of Science and Technology,13 Hangkong Road,Wuhan,Hubei 430030,China [2]Institute of Brain Research,Huazhong University of Science and Technology,13 Hangkong Road,Wuhan,Hubei 430030,China

出　　处：《Chinese Journal of Chemistry》2021年第12期3429-3434,共6页中国化学（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(21877043,21702068,22025102);Wuhan Creative Talent Development Fund,and Fundamental Research Funds for the Central Universities(2017KFYXJJ150)is greatly appreciated;We also thank Analytical and Testing Center of HUST for NMR tests.

摘　　要：Based on the redox reactions of Togni-Ⅱreagent and thiols,a thiol-tuned selective functionalization of unactivated olefins was disclosed.In combination with aryl thiols,stoichiometric amount of Togni-Ⅱreagent prompted a hydrotrifluoromethylation of alkenes,in which,aryl thiols played as reductant and hydrogen source;while by utilization of alkyl thiols,catalytic amount of Togni-Ⅱreagent initiated thiol-ene and thiol-yne reactions.The reported applications are characterized by their operational simplicity and wide functional group tolerance.

关 键 词：Togni-Ⅱreagent Hydrotriflupromethylation Thiol-ene reaction ALKENES Radical reactions 

分 类 号：O62[理学—有机化学]