HICH患者血清凝血酶、MMP-9水平与脑水肿及神经功能缺损的关系  

Relationship between serum thrombin,MMP-9 levels and brain edema and neurological deficit in patients with HICH

作　　者：郑岩[1] ZHENG Yan(Zhengzhou Orthopedic Hospital,Zhengzhou,Henan 450001,China)

机构地区：[1]郑州市骨科医院,河南郑州450001

出　　处：《检验医学与临床》2022年第1期80-83,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨高血压脑出血(HICH)患者血清凝血酶、基质金属蛋白酶9(MMP-9)水平与患者脑水肿程度、神经功能缺损程度的关系。方法选取该院收治的90例HICH患者作为HICH组、45例体检志愿者作为对照组,所有HICH患者均接受血肿清除术,术后接受血肿腔引流及相关支持治疗措施;检测HICH患者起病后第1、3、7天血清凝血酶、MMP-9水平并与对照组进行对比;检测HICH组患者第1、3、7天脑水肿比值及评估患者的神经功能缺损评分(NIHSS)。结果HICH组患者血清凝血酶、MMP-9在起病后第1、3、7天均高于对照组,差异有统计学意义(P<0.05)。HICH组患者脑水肿比值、NIHSS评分在起病后第3天达到峰值后呈逐渐降低的趋势(P<0.05);多元线性回归模型结果显示NIHSS评分与HICH患者的年龄、收缩压、脑出血量、凝血酶及MMP-9水平呈正相关(b=0.381、0.411、0.550、0.641、0.495,P<0.05);脑水肿比值与HICH患者的脑出血量、凝血酶及MMP-9水平呈正相关(b=0.801、0.772、0.581,P<0.05)。结论HICH患者血清凝血酶、MMP-9水平升高,并且与脑水肿及神经功能缺损关系密切。Objective To investigate the relationship between serum thrombin,matrix metalloproteinase 9(MMP-9)in patients with hypertensive intracerebral hemorrhage(HICH)levels and brain edema and neurological deficit.Methods A total of 90 HICH patients admitted to the hospital were selected as the HICH group and 45 physical examination volunteers as the control group.All patients with HICH underwent hematoma evacuation,hematoma drainage and related supportive treatments were performed after surgery;The levels of serum thrombin and MMP-9 on the 1st,3rd and 7th day of the HICH group were detected and compared with the control group.The 1st,3rd and 7th day brain edema ratios of the HICH group and the neurological deficit score(NIHSS)were evaluated.Results Serum thrombin and MMP-9 levels in the HICH group were higher than that in the control group on the 1st,3rd,and 7th day after onset,the difference was statistically significant(P<0.05).The cerebral edema ratio and NIHSS score in the HICH group peaked on the 3rd day after onset,and then gradually decreased(P<0.05).The results of the multiple linear regression model showed that the NIHSS score was positively correlated with the age,systolic blood pressure,cerebral hemorrhage,thrombin and MMP-9 levels in HICH patients(b=0.381,0.411,0.550,0.641,0.495,P<0.05).The brain edema ratio was correlated with cerebral hemorrhage,thrombin and MMP-9 levels(b=0.801,0.772,0.581,P<0.05).Conclusion Serum thrombin and MMP-9 levels increase in HICH patients,and are closely related to brain edema and neurological deficits.

关 键 词：高血压脑出血 凝血酶 基质金属蛋白酶9 脑水肿程度 神经功能缺损程度 

分 类 号：R544.1[医药卫生—心血管疾病]