肿瘤转移前微环境动物模型的构建与评价方法研究进展  

Research progress on the construction and evaluation methods of pre-metastatic niche animal models

作　　者：申明 陈彦文[1] 李杨[1] 杨玲玲[1] 梁乾坤 明海霞[1,2] SHEN Ming;CHEN Yanwen;LI Yang;YANG Lingling;LIANG Qiankun;MING Haixia(Gansu University of Chinese Medicine,Lanzhou 730000;China.2.Institute of Integrative Medicine with Gansu University of Traditional Chinese Medicine,Lanzhou 730000)

机构地区：[1]甘肃中医药大学,兰州730000 [2]甘肃中医药大学中西医结合研究所,兰州730000

出　　处：《中国实验动物学报》2021年第6期839-847,共9页Acta Laboratorium Animalis Scientia Sinica

基　　金：甘肃省科技厅自然科学基金项目(20JR5RA178,20JR10RA320);甘肃省中医药研究中心开放课题(zyzx-2020-zx2);甘肃中医药大学科学研究与创新基金项目(2020KCZD-4,2021KCZD-1);甘肃中医药大学中西医结合基础学科科研培育项目(2020-2021-12);兰州市科技计划项目(2020-ZD-55,2021-1-96);甘肃省教育科技创新项目(2021CXZX-745)。

摘　　要：肿瘤转移是一个庞杂的过程,转移前微环境(PMN)概念的提出,揭示了肿瘤转移的关键因素。实验动物模型在模拟人类的疾病进程、开发新型药物及疗法和临床试验等方面有着巨大的贡献,现已被广泛用于研究肿瘤行为学相关研究,其中肿瘤的肺转移微环境模型具有操作性强、成功率高、实验效果良好等优点。基于肿瘤转移前微环境这一概念,本文围绕肿瘤的肺转移前微环境实验动物模型的构建方法及评价指标展开综述。Tumor metastasis is a complicated process. The concept of the pre-metastatic niche(PMN) reveals the essential factors of tumor metastasis. Experimental animal models have made significant contributions to simulating the process of human diseases, developing new drugs and therapies and clinical trials. In particular, they have been widely used in the study of tumor behavior. The pulmonary metastasis tumor models have the advantages of high reproducibility, high success rates and promising experimental result. Based on the concept of PMN, this article summarizes the method and evaluation indicators of pulmonary metastasis animal models.

关 键 词：肿瘤转移前微环境 肺转移前微环境模型 小鼠 构建与评价方法 

分 类 号：Q95-33[生物学—动物学]