甘舒霖30R联合二甲双胍治疗2型糖尿病的效果  

Effect of Gansulin 30R Combined with Metformin in the Treatment of Type 2 Diabetes

作　　者：孙雪萍 SUN Xueping(Department of Endocrinology,Dandong Hospital of Traditional Chinese Medicine,Dandong 118000,China)

机构地区：[1]丹东市中医院内分泌科,辽宁丹东118000

出　　处：《中国医药指南》2022年第2期118-120,共3页Guide of China Medicine

摘　　要：目的分析2型糖尿病疾病特点,探讨甘舒霖30R联合二甲双胍治疗2型糖尿病的效果,为糖尿病治疗工作提供参考。方法选择我院2018年3月至2019年5月内分泌科收治的2型糖尿病患者为例进行研究,总计94例。按照随机数字表法分为两组,对照组与研究组各47例,经伦理委员会审核批准。对照组糖尿病患者仅采用二甲双胍治疗,研究组糖尿病患者采用甘舒霖30R联合二甲双胍治疗。比较两组糖尿病患者治疗后情况,包括治疗前后测定体质量指数(body mass index,BMI)、空腹血糖(fasting plasma glucose,FPG)、餐后2 h血糖(2 h-postprandial plasma glucose,2 h PG)、糖化血红蛋白(glycated hemoglobin,HbA1c),以及血脂,包括胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)和低密度脂蛋白(low-density lipoprotein,LDL-C)水平变化情况以及不良反应情况。结果治疗后,研究组患者的BMI为(22.14±0.57)kg/m2、FPG为(6.44±0.72)mmol/L、2 h PG为(8.47±0.68)mmol/L、HBA1c为(6.47±0.73)%,对照组患者的分别为(23.52±0.82)kg/m2、(6.82±0.56)mmol/L、(9.15±0.73)mmol/L、(7.46±0.80)%。组间各项指标数据比较,差异有统计学意义(P<0.05)。治疗后研究组患者的TC为(4.03±0.62)mmol/L、TG为(1.38±0.58)mmol/L、LDL-C为(2.51±0.78)mmol/L,对照组患者的分别为(5.12±0.77)mmol/L、(1.63±0.75)mmol/L、(2.97±0.63)mmol/L。组间各项指标数据比较,差异有统计学意义(P<0.05)。组间用药后不良反应发生情况比较,两组患者恶心、皮疹、体质量增加等不良反应发生情况接近,P>0.05。结论对比单一治疗,甘舒霖30R联合二甲双胍治疗2型糖尿病,能够更有效地控制血糖,并降低血脂,降低体质量,且用药安全性理想,是优选治疗方案。Objective To analyze the characteristics of type 2 diabetes,and to explore the effect of Ganshulin 30R combined with metformin in the treatment of type 2 diabetes,so as to provide reference for the treatment of diabetes.Methods Selected patients with type 2 diabetes who were admitted to the Department of Endocrinology in our hospital from March 2018 to May 2019 as an example for the study,with a total of 94 cases.According to the random number table method,they were divided into two groups,the control group and the study group had 47 cases each,which were reviewed and approved by the ethics committee.The diabetic patients in the control group were treated with metformin only,and the diabetic patients in the study group were treated with Ganshulin 30R combined with metformin.Compare the two groups of diabetic patients after treatment,including measuring body mass index(BMI),fasting plasma glucose(FPG),2 hours Postprandial Plasma Glucose(2 h PG),and glycation before and after treatment.Glycated hemoglobin(HbA1c),and blood lipids,including cholesterol(total cholesterol,TC),triglyceride(TG)and low-density lipoprotein(LDL-C)level changes and adverse reactions.Results After treatment,the BMI of the patients in the study group was(22.14±0.57)kg/m^(2),FPG was(6.44±0.72)mmol/L,2 h PG was(8.47±0.68)mmol/L,and HBA1c was(6.47±0.73)%,The patients in the control group were(23.52±0.82)kg/m^(2),(6.82±0.56)mmol/L,(9.15±0.73)mmol/L,(7.46±0.80)%,respectively.The comparison of various index data between the groups was statistically significant(P<0.05).After treatment,the TC of the study group was(4.03±0.62)mmol/L,the TG was(1.38±0.58)mmol/L,and the LDL-C was(2.51±0.78)mmol/L,and the control group was(5.12±0.77)mmol/L,(1.63±0.75)mmol/L,(2.97±0.63)mmol/L.The comparison of various index data between the groups was statistically significant(P<0.05).The incidence of adverse reactions after medication was compared between the two groups.The incidence of adverse reactions such as nausea,rash,and weight gain was similar betwee

关 键 词：2型糖尿病 甘舒霖30R 二甲双胍 血糖水平 血脂水平 联合治疗 不良反应情况 

分 类 号：R587.1[医药卫生—内分泌]