微波消融联合LT4治疗NNG的临床疗效  

Clinical effect of microwave ablation combined with LT4 on NNG

作　　者：黄汉伟[1] 熊晓慧 刘裕[1] HUANG Hanwei;XIONG Xiaohui;LIU Yu(Zhongshan Chenxinghai Hospital,Zhongshan,Guangdong 528415,China)

机构地区：[1]中山市陈星海医院,广东中山528415

出　　处：《现代医药卫生》2022年第1期25-30,共6页Journal of Modern Medicine & Health

基　　金：中山市科学技术局社会公益科技研究专项基金项目(中山科发〔2018〕174号)。

摘　　要：目的探讨微波消融(MWA)术后应用左甲状腺素钠(LT4)25μg,每天1次,治疗非毒性结节性甲状腺肿(NNG)的临床疗效,以及观察术后促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb)的变化。方法收集2017年1月至2019年7月中山市陈星海医院院NNG患者60例,将其随机分为治疗组30例,采用MWA术后服用LT4(每次25μg,每天1次)12个月;对照组30例,仅用MWA术,并进行术后1、3、6、12个月随访。结果与对照组比较,治疗组术后应用LT4(每次25μg,每天1次)使TSH处于在正常低值,差异有统计学意义(P<0.05),但并未明显加速消融后结节的吸收,差异无统计学意义(P>0.05);两组TPOAb、TgAb比较,差异均无统计学意义(P>0.05)。结论MWA术后应用LT4治疗NNG,对于加速消融后结节吸收疗效并不显著;MWA术及MWA术后联用LT4对TPOAb、TgAb均无显著影响。Objective To investigate the clinical effect of taking levothyroxine sodium(LT4)25μg/qd in the treatment of non-toxic nodular goiter(NNG)after microwave ablation(MWA),and to observe the chan-ges of postoperative thyrotropin(TSH),thyroperoxidase antibody(TPOAb),and thyroglobulin antibody(TgAb).Methods We collected 60 patients with NNG in our hospital,and randomly divided them into treat-ment group 30 patients,taking LT4(25μg/qd)for 12 months after MWA operation,and control group 30 pa-tients with MWA operation only,and followed up 1,3,6 and 12 months after operation.Results The postop-erative application of LT4(25μg/qd)in the treatment group kept the TSH at a normal low value(P<0.05),but did not significantly accelerate the absorption of nodules(P>0.05)after ablation;there was no significant change in the TPOAb,TgAb between the two groups(P>0.05).Conclusion MWA postoperative use of LT4 therapy NNG,for accelerated ablation of nodule absorption effect is not significant;MWA and combined LT4 have no significant impact on TPOAb,TgAb.

关 键 词：非毒性结节性甲状腺肿 微波消融 甲状腺自身抗体 左甲状腺素钠 

分 类 号：R581.3[医药卫生—内分泌]