硬皮病皮肤硬化程度评估方法及其技术进展  

Progress in methods and techniques for evaluating the skin hardness degree of scleroderma

作　　者：王修远 杨骥 WANG Xiu-yuan;YANG Ji(Department of Dermatology,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院皮肤科,上海200032

出　　处：《中国临床医学》2021年第6期948-951,共4页Chinese Journal of Clinical Medicine

基　　金：上海市科学技术委员会医学引导类项目(19411962500);上海市杰出青年医学人才项目,复旦大学“卓越2025”——卓学优秀人才层次项目.

摘　　要：硬皮病是一种以成纤维细胞增殖、胶原合成增多、皮肤增厚和硬化为主要表现,并可以引起多系统损害的结缔组织病,发病机制复杂。皮肤硬化是硬皮病普遍的标志性病变。早期快速进展的弥漫性皮肤硬化与内脏受累和死亡率升高相关,皮肤硬化的改善则提示病情缓解和较好的预后。但是目前皮肤硬化缺乏敏感而特异的客观评价方法,进而限制了医师对硬皮病疗效和预后的准确判断。本文对相关领域内容及研究进展作一综述,以期对硬皮病的研究有一定帮助。Scleroderma is a kind of connective tissue disease characterized by fibroblast proliferation,collagen synthesis increase,and skin hardening and thickening,which has complex pathogenesis and can cause multiple system damage.Skin sclerosis is a common sign of scleroderma.Early diffuse and rapid skin sclerosis is thought to be associated with increased risk of organ involvement and mortality.Instead,skin sclerosis remission suggests a better prognosis.However,there are no sensitive and specific objective evaluation methods currently,which limits the accurate judgment of the therapeutic effect and prognosis of scleroderma.This paper reviews the research progress in related fields,hoping to be helpful for the study of scleroderma.

关 键 词：硬皮病 硬度 皮肤评分 评估方法 

分 类 号：R593.25[医药卫生—内科学]