纳米纤维素基血液接触性材料研究进展  

Research Advances on Nanocellulose-based Blood-contact Materials

作　　者：张春亮 吴治宇 张瑜[4] 杨培[5] 王凯荣 周风山[1] 王小慧 ZHANG Chunliang;WU Zhiyu;ZHANG Yu;YANG Pei;WANG Kairong;ZHOU Fengshan;WANG Xiaohui(School of Materials Science and Engineering,China University of Geosciences(Beijing),Beijing,100083;National Central of Nanoscience and Technology,Beijing,100190;The First Clinical Medical College of Lanzhou University,Lanzhou,Gansu Province,730000;Beijing Anzhen Hospital Affiliated to Capital Medical University,Beijing,100029;General Hospital of Ningxia Medical University,Yinchuan,Ningxia Hui Autonomous Region,750004;Institute of Biochemistry and Molecular Biology,School of Basic Medicine,Lanzhou University,Lanzhou,Gansu Province,730000;Institute of Health Service and Transfusion Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing,100850)

机构地区：[1]中国地质大学(北京)材料科学与工程学院,北京100083 [2]国家纳米科学中心,北京100190 [3]兰州大学第一临床医学院,甘肃兰州730000 [4]首都医科大学附属北京安贞医院,北京100029 [5]宁夏医科大学总医院,宁夏银川750004 [6]兰州大学基础医学院生物化学与分子生物学研究所,甘肃兰州730000 [7]军事科学院军事医学研究院卫生勤务与血液研究所,北京100850

出　　处：《中国造纸》2021年第11期134-142,共9页China Pulp & Paper

基　　金：国家自然科学基金(21875050);宁夏回族自治区重点研发计划(2020ZDYF0786)。

摘　　要：纳米纤维素是在某一尺度上具有纳米级的纤维素材料,其具有优异的力学性能和良好的生物相容性,在血液接触性材料领域得到了迅速的发展。纳米纤维素材料具有可控的血液相容性,作为抗凝血材料和促凝血材料具有广泛的应用前景。本文讨论了纳米纤维素基血液接触性材料的制备方法,总结了其在抗凝血与促凝血中的应用,并就其未来应用进行了展望。Nanocellulose is a kind of cellulose material with one or more dimensions in nanoscale,and has excellent mechanical properties and good biocompatibility which render its rapid development in the field of blood-contact materials.Nanocellulose materials are of controllable blood compatibility,therefore,have wide application prospects in the field of anticoagulant and procoagulant materials.In the paper,the preparation of nanocellulose-based blood contact materials were discussed,their applications as anticoagulant and procoagulant materials were summarized,and their future applications were prospected.

关 键 词：纤维素纳米纤丝 纤维素纳米晶体 细菌纤维素 抗凝血材料 促凝血材料 

分 类 号：TS721[轻工技术与工程—制浆造纸工程]