胰腺炎患犬肠道菌群构成的多样性分析  

Diversity Analysis of Gut Microbiota in Pancreatitis Dogs

作　　者：项夫[1,2] 杨晓雯 王家伟 吴清民 XIANG Fu;YANG Xiao-wen;WANG Jia-wei;WU Qing-min(College of Veterinary Medicine,China Agricultural University,Beijing 100193,China;Beijing Pets International Animal Hospital,Beijing 100124,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]中国农业大学动物医学院,北京海淀100193 [2]北京宠爱国际动物医院,北京朝阳100124 [3]中国疾病预防控制中心传染病预防控制所,北京昌平102206

出　　处：《中国兽医杂志》2021年第9期91-95,共5页Chinese Journal of Veterinary Medicine

摘　　要：为探索健康犬与胰腺炎患犬肠道菌群的多样性及丰度,本试验基于扩增子测序技术,分别对健康犬和胰腺炎患犬粪便样品进行检测,比较两者肠道菌群组成及多样性差异。测序数据聚类及分析结果表明,胰腺炎患犬肠道菌群组成及α-多样性显著降低,有益菌群如乳杆菌属丰度与健康犬差异显著;总体上肠道菌群功能不受影响,但部分菌群的功能,如对遗传信息过程等方面受到较大影响。本试验所揭示的胰腺炎患犬肠道菌群组成及多样性,为胰腺炎患犬肠道菌群组成提供了基础数据,同时也为胰腺炎患犬的治疗提供了新思路。The aim of this study was to assess the diversity and abundance of gut microbiota in healthy and pancreatitis dogs.Based on amplicon sequencing technology,stool samples from healthy dogs and dogs suffering from pancreatitis were detected to compare the composition and diversity of intestinal flora between them.Through clustering and analysis of sequencing data,this study showed that the composition and α-diversity of gut microbiota were significantly reduced in pancreatitis dogs compared to healthy dogs.Also,the abundance of beneficial microbiota such as Lactobacillus was significantly different in pancreatitis dogs relative to healthy dogs.Further,the functional compositions of the gut microbiota were similar between healthy and pancreatitis dogs,but some functions,such as genetic information processing,may be affected by pancreatitis.By confirming the negative impact of pancreatitis on the composition and diversity of the gut microbiota in dogs,this study opened a new avenue for improving the treatment of pancreatitis in dogs.

关 键 词：犬 胰腺炎 肠道菌群 多样性 

分 类 号：S858.292[农业科学—临床兽医学]