脂必泰胶囊在膜性肾病中的疗效观察  

Observation on the efficacy of Zhibitai capsules in membranous nephropathy

作　　者：孔爱丽[1] 仇晓玲[1] KONG Ai-li;QIU Xiaoling(Department of Nephrology,Huludao Central Hospital,Huludao 125001,China)

机构地区：[1]葫芦岛市中心医院肾内科,125001

出　　处：《中国实用医药》2021年第36期18-21,共4页China Practical Medicine

摘　　要：目的观察分析脂必泰胶囊在膜性肾病患者治疗中的临床效果。方法60例膜性肾病患者,按随机数字表法分为观察组和对照组,各30例。对照组给予盐酸贝那普利片治疗,观察组在对照组基础上联合应用脂必泰胶囊治疗。比较两组治疗前后的24 h尿蛋白定量、血清白蛋白(Alb)、血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、炎性因子[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、超敏C反应蛋白(hs-CRP)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)]、不良反应发生情况。结果治疗后,两组24 h尿蛋白定量较治疗前降低,Alb较治疗前升高,且观察组24 h尿蛋白定量(1.93±0.29)g/24 h低于对照组的(2.70±0.34)g/24 h,Alb(38.23±1.53)g/L高于对照组的(33.90±1.52)g/L,差异有统计学意义(P<0.05)。治疗后,观察组TG、TC、LDL-C较治疗前降低,HDL-C较治疗前增高,差异有统计学意义(P<0.05);观察组TG、TC、LDL-C分别为(1.95±0.36)、(4.65±0.68)、(3.34±0.35)mmol/L,均低于对照组的(2.45±0.42)、(6.11±0.54)、(4.25±0.34)mmol/L,HDL-C(1.35±0.23)mmol/L高于对照组的(1.14±0.15)mmol/L,差异均有统计学意义(P<0.05)。治疗后,观察组IL-6、IL-8、hs-CRP较治疗前降低,差异有统计学意义(P<0.05);观察组IL-6、IL-8、hs-CRP分别为(22.54±3.78)pg/ml、(4.01±0.62)pg/ml、(5.90±1.13)mg/L,均低于对照组的(29.50±4.05)pg/ml、(5.30±0.60)pg/ml、(9.90±1.26)mg/L,差异有统计学意义(P<0.05)。治疗后,观察组MDA较治疗前降低,SOD、GSH-Px较治疗前升高,差异有统计学意义(P<0.05);观察组MDA(16.72±5.25)μmol/L低于对照组的(24.98±5.20)μmol/L,SOD(120.42±21.44)kU/L、GSH-Px(138.02±19.70)mg/L高于对照组的(84.25±20.02)kU/L、(127.51±20.90)mg/L,差异有统计学意义(P<0.05)。治疗过程中无患者脱落,两组无严重不良反应出现。结论脂必泰联合贝那普利片可有�Objective To observe and analyze the clinical effect of Zhibitai capsules in membranous nephropathy.Methods A total of 60 patients with membranous nephropathy were divided into observation group and control group according to the random numerical table,with 30 cases in each group.The control group was treated with benazepril hydrochloride tablets,and the observation group was treated with Zhibitai capsules on the basis of the control group.Both groups were compared in terms of 24 h urinary protein quantification,serum albumin(Alb),blood lipids[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)],inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),high-sensitivity C-reactive protein(hs-CRP)],oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px)]before and after treatment,and occurrence of adverse reactions.Results After treatment,the 24-h urinary protein quantification was lower and Alb was higher in both groups compared to those before treatment;the 24-h urinary protein quantification(1.93±0.29)g/24 h in the observation group was lower than(2.70±0.34)g/24 h in the control group,and Alb(38.23±1.53)g/L was higher than(33.90±1.52)g/L in the control group;all differences were statistically significant(P<0.05).After treatment,the TG,TC and LDL-C were lower and HDL-C was higher in the observation group compared with those before treatment,and the differences were statistically significant(P<0.05).The TG,TC and LDL-C of the observation group were(1.95±0.36),(4.65±0.68),(3.34±0.35)mmol/L,which were lower than(2.45±0.42),(6.11±0.54),(4.25±0.34)mmol/L of the control group,and the HDL-C(1.35±0.23)mmol/L was higher than(1.14±0.15)mmol/L of the control group.All differences were statistically significant(P<0.05).After treatment,the IL-6,IL-8 and hs-CRP in the observation group were lower than those in this group before treatment,and the difference was statistically significant

关 键 词：脂必泰 贝那普利 膜性肾病 高脂血症 炎性因子 氧化应激 

分 类 号：R692[医药卫生—泌尿科学]