从“线粒体-肠道菌群交互作用”探讨益气化痰通络法治疗缺血性中风  

Discussion on the Method of Supplementing Qi, Resolving Phlegm and Dredging Collaterals in the Treatment of Ischemic Stroke from the "Microbiota-Mitochondria Crosstalk"

作　　者：马妍[1] 吴丹 仲爱芹[3] 张伟[4] 张琳琳[1] 王凯[1] 李斌 何剑炜[1] MA Yan;WU Dan;ZHONG Aiqin;ZHANG Wei;ZHANG Linlin;WANG Kai;LI Bin;HE Jianwei(The Second Affiliated Hospital of Tianjin University of Chinese Medicine,Tianjin China 300150;The Second Hospital of Tianjin Medical University,Tianjin China 300211;The First Affiliated Hospital of Tianjin University of Chinese Medicine,Tianjin China 300193;Tianjin University of Chinese Medicine,Tianjin China 301617)

机构地区：[1]天津中医药大学第二附属医院,天津300150 [2]天津医科大学第二医院,天津300211 [3]天津中医药大学第一附属医院,天津300193 [4]天津中医药大学,天津301617

出　　处：《中医学报》2022年第1期24-28,共5页Acta Chinese Medicine

基　　金：国家自然科学基金项目(81804049)。

摘　　要：线粒体结构的完整性及功能被破坏是缺血性脑卒中的主要病理环节之一。"线粒体-肠道菌群交互作用"体现了中医整体观,是人体气与血,正与邪,气机运行和病理产物之间平衡与失衡的一个体现。线粒体功能障碍、肠道菌群失调与中医"气虚""痰浊""瘀血"的机理有相似之处。益气化痰通络法可通过保护线粒体、干预肠道菌群的作用调节机体的气血平衡,达到益气化瘀、补气化痰、活血通络、扶正祛邪的作用。The destruction of mitochondrial structural integrity and function is one of the main pathological links of ischemic stroke. "Microbiota-mitochondria crosstalk" embodies the holistic view of Chinese medicine, and is an embodiment of the balance and imbalance between qi and blood, positive and pathogen, the operation of qi movement and pathological products.Mitochondrial dysfunction and intestinal flora imbalance are similar to the mechanisms of "qi deficiency", "phlegm turbidity" and "blood stasis" in Chinese medicine.Mitochondrial dysfunction and intestinal flora imbalance are similar to the mechanisms of "qi Deficiency", "phlegm turbidity" and "blood stasis" in Chinese medicine.The method of supplementing qi, resolving phlegm and dredging collaterals can regulate the balance of qi and blood by protecting mitochondria and interfering with intestinal flora, so as to achieve the effects of supplementing qi and removing blood stasis, supplementing qi and resolving phlegm, activating blood circulation and dredging collaterals, supporting vital qi and eliminating pathogen.

关 键 词：益气化痰通络法 “线粒体-肠道菌群交互作用” 缺血性中风 

分 类 号：R255.2[医药卫生—中医内科学]