弥凝联合托特罗定治疗儿童原发性夜遗尿临床观察  

Clinical observation of desmopressin combined with tolterodine in the treatment of primary nocturnal enuresis in children

作　　者：郭银霞 肖小兵[1] 邓建荣[1] 胡瑛 高盈竹 钟美香 GUO Yin-xia;XIAO Xiao-bing;DENG Jian-rong;HU Ying;GAO Ying-zhu;ZHONG Mei-xiang(Department of Pediatrics,North Guangdong People's Hospital,Shaoguan 512025,Guangdong,CHINA)

机构地区：[1]粤北人民医院儿科,广东韶关512025

出　　处：《海南医学》2022年第1期65-67,共3页Hainan Medical Journal

基　　金：广东省韶关市卫生健康局科研计划项目(编号:Y21058)。

摘　　要：目的观察弥凝联合托特罗定治疗儿童原发性夜遗尿的临床疗效及安全性。方法选择2018年1月至2020年8月粤北人民医院儿科门诊收治的60例原发性夜遗尿患儿作为研究对象,按照随机数表法分为观察组和对照组各30例。对照组患儿在常规措施基础上采用弥凝治疗,观察组在对照组治疗的基础上联合托特罗定治疗,均持续治疗3个月。比较两组患儿治疗3个月后的临床疗效,治疗前、治疗3个月后的夜间遗尿次数、夜间遗尿尿量的变化,以及停药后1个月、3个月的复发率和治疗期间不良反应发生情况。结果治疗后,观察组患儿的临床治疗总有效率为93.33%,明显高于对照组的73.33%,差异有统计学意义(P<0.05);治疗后,观察组患儿的夜间遗尿次数、夜间遗尿尿量分别为(1.17±0.20)周、(101.45±12.02) mL,明显少于对照组的(1.45±0.23)周、(111.43±10.87) mL,差异均有统计学意义(P<0.05);观察组患儿停药后1个月、3个月的复发率分别为3.33%和6.67%,明显低于对照组的20.00%和26.67%,差异均有统计学意义(P<0.05);观察组和对照组患儿不良反应总发生率分别为13.33%和10.00%,差异无统计学意义(P>0.05)。结论弥凝联合托特罗定治疗儿童原发性夜遗尿的临床疗效明显,值得临床推广。Objective To study the curative efficacy of desmopressin combined with tolterodine in the treatment of primary nocturnal enuresis in children. Methods A total of 60 patients of primary nocturnal enuresis, who admitted to the Outpatient Department of pediatrics, North Guangdong People’s Hospital from January 2018 to August2020, were selected and divided into the observation group and control group according to random number table method,with 30 patients in each group. The control group was treated with desmopressin on the basis of conventional measures,while the observation group was combined with tolterodine on the basis of the control group. The treatment lasted 3 months. The clinical effects at 3 months after treatment, the nocturnal enuresis frequency and nocturnal enuresis urine volume before and at 3 months after treatment, and the recurrence rate at 1 month and 3 months after drug withdrawal and the incidence of adverse reactions during treatment of two groups children were compared. Results After treatment, the total effective rate in the observation group was 93.33%, which was significantly higher than 73.33% of the control group(P<0.05);after treatment, the nocturnal enuresis frequency and nocturnal enuresis urine volume in the observation group were(1.17 ± 0.20) weeks and(101.45 ± 12.02) mL, which were significantly less than corresponding(1.45±0.23) weeks and(111.43±10.87) mL of the control group(P<0.05);after 1 month and 3 months drug withdrawal,the recurrence rates in the observation group were 3.33% and 6.67%, which were significantly lower than corresponding20.00% and 26.67% of the control group(P<0.05);the total incidence of adverse reactions in the observation group was13.33% versus 10.00% in the control group(P>0.05). Conclusion Desmopressin combined with tolterodine in the treatment of children with primary nocturnal enuresis has obvious clinical effect and is worthy of clinical promotion.

关 键 词：原发性夜遗尿 儿童 弥凝 托特罗定 疗效 不良反应 

分 类 号：R726.9[医药卫生—儿科]