男性生殖器硬化性苔藓样变发病机制与治疗的最新进展  

Recent advances in the pathogenesis and treatment of male genital lichen sclerosus

作　　者：杨健 谢文贤 曾柯[1] YANG Jian;XIE Wen-xian;ZENG Ke(Department of Urology,Zigong First People's Hospital,Zigong 643000,Sichuan,CHINA;Department of Basic Medicine,Sichuan Vocational College of Health And Rehabilitation,Zigong 643000,Sichuan,CHINA)

机构地区：[1]自贡市第一人民医院泌尿外科,四川自贡643000 [2]四川省卫生康复职业学院基础教研室,四川自贡643000

出　　处：《海南医学》2022年第1期108-112,共5页Hainan Medical Journal

基　　金：四川省自贡市卫生健康委员会科研课题(编号:20zd004)。

摘　　要：男性生殖器硬化性苔藓样变(MGLSc)是一种慢性炎症性皮肤病,常引起男性性交困难和前尿道狭窄,甚至可演变成阴茎鳞状细胞癌(PSCC)。虽然发病原因众多,但是长期的尿液浸蚀而引起包皮、龟头慢性炎症是最核心的病理机制。对于早期MGLSc的治疗方法是局部使用皮质类固醇激素;对于药物治疗无效、尿道狭窄、鳞状细胞癌的患者应进行手术治疗。光动力治疗具有微创、无毒、安全便捷等优点,对于早期的MGLSc患者可能是一种理想的治疗方式。Male genital lichen sclerosus(MGLSc) is a chronic inflammatory skin disease, which often causes male sexual difficulties and anterior urethral stricture, and even develops into penile squamous cell carcinoma(PSCC).Although there are many causes, chronic inflammation of prepuce and glans caused by long-term urine erosion is the core pathological mechanism. The treatment of early MGLSc is local corticosteroid. Surgical treatment should be performed in patients with drug failure, urethral stricture and squamous cell carcinoma. Photodynamic therapy is minimally invasive, non-toxic, safe and convenient, which may be an ideal treatment for early MGLSc patients.

关 键 词：男性生殖器硬化性苔藓样变 感染 阴茎鳞状细胞癌 微尿失禁 光动力治疗 

分 类 号：R699[医药卫生—泌尿科学]