PTEN/NF-κB信号通路在肾脏疾病中的研究进展  

Research Progress of PTEN/NF-κB Signaling Pathway in Renal Diseases

作　　者：陈文熙 文青 李智恒 蔡雪妮 严瑞 CHEN Wenxi;WEN Qing;LI Zhiheng;CAI Xueni;YAN Rui(Department of Nephrology,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学附属医院肾内科,贵阳550004

出　　处：《医学综述》2022年第1期12-17,共6页Medical Recapitulate

基　　金：国家自然科学基金(81960140);贵州省科技计划项目(黔科合基础-ZK〔2021〕一般379)。

摘　　要：肾脏疾病患者体内广泛存在慢性炎症状态,慢性炎症反应是肾脏疾病发生、发展以及恶化的重要因素之一。细胞焦亡作为一种炎症细胞死亡方式参与多种肾脏疾病的发生发展过程。而人第10号染色体缺失的磷酸酶及张力蛋白同源基因(PTEN)与核因子κB(NF-κB)在肾脏疾病中参与细胞焦亡的发生过程,且PTEN与NF-κB可能存在相互调控的关系。其中,NF-κB在调节细胞反应中具有重要作用,是对有害细胞刺激的第一反应者,而靶向抑制NF-κB是肾脏疾病治疗的研究方向之一。因此,全面研究PTEN/NF-κB信号通路在急慢性肾脏病中的作用机制将为肾脏疾病的早期诊断及靶向治疗提供理论依据,并为临床治疗肾脏疾病提供新思路。Chronic inflammation is widespread in patients with kidney diseases,and it is one of the important factors for the occurrence,development and deterioration of kidney diseases.Pyroptosis,as an inflammatory cell death mode,is involved in the occurrence and development of many renal diseases.Phosphatase and tensin homologue deleted on chromosome ten gene(PTEN)and nuclear factor-κB(NF-κB)are involved in the pathogenesis of cell pyroptosis in renal diseases,and the relationship between PTEN and NF-κB may be mutual regulation.NF-κB plays an important role in regulating cellular response and is the first responsor to harmful cell stimulation.The targeted inhibition of NF-κB is one of the research directions in the treatment of kidney diseases.Therefore,a comprehensive study on the mechanism of PTEN/NF-κB signaling pathway in acute and chronic kidney diseases will provide theoretical basis for the early diagnosis and targeted therapy of kidney diseases,and bring new ideas for the clinical treatment.

关 键 词：肾脏疾病 细胞焦亡 人第10号染色体缺失的磷酸酶及张力蛋白同源基因/核因子κB信号通路 

分 类 号：R692[医药卫生—泌尿科学]