重组人粒细胞集落刺激因子和重组人白介素-11联合应用致过敏性休克1例  

Anaphylactic shock induced by recombinant human granulocyte colony stimulating factor combined with recombinant human interleukin-11:a case report

作　　者：闵现华[1] 孙鹏飞[1] 张小兰 曹向荣[1] MIN Xianhua;SUN Pengfei;ZHANG Xiaolan;CAO Xiangrong(Department of Radiotherapy,Lanzhou University Second Hospital,Lanzhou,Gansu,730030,China)

机构地区：[1]兰州大学第二医院放疗科,甘肃兰州730030

出　　处：《肿瘤药学》2021年第6期775-778,共4页Anti-Tumor Pharmacy

基　　金：2021年度甘肃省高等学校创新基金项目(2021B-053)。

摘　　要：报道1例42岁女性小细胞肺癌维持化疗患者应用重组人粒细胞集落刺激因子(rhG-CSF)150μg联合重组人白介素-11(rhIL-11)3 mg治疗的情况。给药10 min后,患者出现全身皮疹、血压下降、意识模糊等过敏性休克症状,给予地塞米松、肾上腺素、多巴胺、氢化可的松等对症支持治疗后恢复。Here reported was a case of 42-year-old female with small cell lung cancer undergoing maintenance chemotherapy.The patient was treated with recombinant human granulocyte colony stimulating factor(rhG-CSF)150μg and recombinant human interleukin-11(rhIL-11)3 mg.Ten minutes after injection,the patient appeared anaphylactic shock symptoms such as systemic rash,hypotension and confusion of consciousness.After treatment with dexamethasone,adrenaline,dopamine,hydrocortisone and other symptomatic support,the patient recovered to normal.

关 键 词：RHG-CSF RHIL-11 过敏性休克 

分 类 号：R734.2[医药卫生—肿瘤] R969.3[医药卫生—临床医学]