Boston Ivy-Inspired Disc-Like Adhesive Microparticles for Drug Delivery  

作　　者：Lijun Cai Guopu Chen Yuetong Wang Cheng Zhao Luoran Shang Yuanjin Zhao 

机构地区：[1]State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [2]Zhongshan-Xuhui Hospital,The Shanghai Key Laboratory of Medical Epigenetics,The International Co-Laboratory of Medical Epigenetics and Metabolism,Ministry of Science and Technology,and Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China [3]Department of Rheumatology Immunology,Institute of Translational Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210008,China

出　　处：《Research》2021年第1期1604-1614,共11页研究（英文）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52073060 and 61927805);the Natural Science Foundation of Jiangsu(BE2018707);the Shenzhen Fundamental Research Program(JCYJ20190813152616459).

摘　　要：Microparticles with strong adherence are expected as efficient drug delivery vehicles.Herein,we presented an ingenious hydrogel microparticle recapitulating the adhesion mechanism of Boston ivy tendrils adhesive discs(AD)for durable drug delivery.The particles were achieved by replicating a silica colloidal crystal aggregates assembled in a droplet template after rapid solvent extraction.Due to their unique shape,the nanostructure,and the sticky hydrogel component,such novel microparticles exhibited prominent adhesive property to the wet tissue environment.It was demonstrated that the bioinspired microcarriers loading with dexamethasone had a good therapeutic effect for ulcerative colitis due to the strong adhesion ability for prolonging the maintenance of drug availability.These virtues make the biomimetic microparticles potentially ideal for many practical clinical applications,such as drug delivery,bioimaging,and biodiagnostics.

关 键 词：environment BOSTON TEMPLATE 

分 类 号：Q81[生物学—生物工程]