一种新型镍基配合物与牛血清白蛋白的作用机理研究  

Study on the mechanism of interaction between a new nickel-based complex and bovine serum albumin

作　　者：海文丽 马小燕 左伟响 宋欢 李冰[1] HAI Wenli;MA Xiaoyan;ZUO Weixiang;SONG Huan;LI Bing(College of Chemistry and Chemical Engineering of Ningxia University,Yinchuan Ningxia 750021,China)

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021

出　　处：《石油化工应用》2021年第12期100-102,共3页Petrochemical Industry Application

基　　金：宁夏大学大学生创新创业训练计划国家级项目,项目编号:G2021107490014。

摘　　要：以5-三氟甲基吡啶-2-甲酸(Htpc)为配体,通过扩散法制备了一种新型镍基配合物[Ni(Htpc)_(2)(H_(2)O)_(2)],并对其进行了粉末衍射、热重和元素分析等表征,分析了其结构。荧光光谱表明配合物[Ni(Htpc)_(2)(H_(2)O)_(2)]对牛血清白蛋白(BSA)的作用为静态猝灭,配合物的结合常数增大,结合力更强。A new nickel based complex[Ni(Htpc)_(2)(H_(2)O)_(2)]was prepared by diffusion method with 5-trifluoromethylpyridine-2-carboxylic acid(Htpc)as ligand.Its structure was characterized by powder diffraction,thermogravimetric analysis and elemental analysis.The fluorescence spectra showed that the effect of[Ni(Htpc)_(2)(H_(2)O)_(2)]on bovine serum albumin(BSA)was static quenching,and the binding constant of[Ni(Htpc)_(2)(H_(2)O)_(2)]increased,as well as the binding force was stronger.

关 键 词：5-三氟甲基吡啶-2-甲酸 配合物 牛血清白蛋白 机理 

分 类 号：O622[理学—有机化学]