药物涂层球囊与普通球囊治疗自体动静脉内瘘狭窄疗效对比的Meta分析  

Comparison of drug-coated balloon angioplasty versus plain old balloon angioplasty for arterio-venous fistula stenosis:a Meta-analysis

作　　者：徐一丁 朱峥嵘[1] 邹岚[1] 邢越[1] 吴嘉瑜 曹健强[1] 谭羽灿[1] 罗灿华[1] Xu Yiding;Zhu Zhengrong;Zou Lan;Xing Yue;Wu Jiayu;Cao Jianqiang;Tan Yucan;Luo Canhua(Department of Vascular Surgery,The First People's Hospital of Foshan,Foshan 528000,China)

机构地区：[1]佛山市第一人民医院血管外科,广东佛山528000

出　　处：《中国血管外科杂志（电子版）》2021年第4期341-345,共5页Chinese Journal of Vascular Surgery(Electronic Version)

摘　　要：目的比较药物涂层球囊(drug-coated balloon,DCB)与普通球囊扩张(plain old balloon angioplasty,POBA)治疗AVF狭窄的安全性和有效性。方法计算机检索PubMed、Cochrane Library、中国知网、万方数据库和维普数据库关于DCB与POBA治疗AVF狭窄的RCT研究,时间均从建库至2021年3月,采用RevMan5.3软件对入选文献进行Meta分析。结果共8篇RCT文献纳入分析,患者1064例,其中采取DCB治疗538例(DCB组),采取POBA治疗的526例(POBA组)。Meta分析结果显示,两组患者术后6个月(OR=0.96,95%CI=0.56~1.67,P=0.90)和12个月(OR=1.06,95%CI=0.59~1.91,P=0.84)的全因死亡率差异无统计学意义;与POBA组相比,DCB组在术后6个月(OR=2.42,95%CI=1.59~3.69,P<0.01)和12个月(OR=4.65,95%CI=1.3~16.61,P<0.01)的靶病变一期通畅率更高,差异有统计学意义。结论DCB治疗AVF狭窄能提高靶病变的一期通畅率,且目前没有证据表明DCB会增加AVF狭窄患者的死亡率。Objective To compare the safety and efficacy of drug-coated balloon(DCB)angioplasty and plain old balloon angioplasty(POBA)in the treatment of arteriovenous fistula(AVF)stenosis.Methods The randomized controlled trial(RCT)literatures for comparing DCB versus POBA for the treatment of AVF stenosis in databases including PubMed,Cochrane Library,CNKI,Wanfang and VIP were researched.The retrieval time was from the establishment of data base to March 2021.RevMan5.3 software was used for Meta analysis.Results A total of 8 RCTs were included in this Meta-analysis.1064 patients were involved,including 538 were treated with DCB(DCB group)and 526 were treated with POBA(POBA group).Meta-analysis results showed there were no statistically significant difference in all-cause mortality of two groups in 6 months(OR=0.96,95%CI=0.56~1.67,P=0.90)and 12 months(OR=1.06,95%CI=0.59~1.91,P=0.84)after surgery.Compared with POBA group,DCB group had higher first-stage patency rate of the target lesion in 6 months(OR=2.42,95%CI=1.59~3.69,P<0.01)and 12 months(OR=4.65,95%CI=1.3~16.61,P<0.01)after surgery,and the difference was statistically significant.Conclusion DCB treatment for AVF stenosis can increase the primary patency rate of target lesions,and there is currently no evidence that DCB can increase the mortality of patients with AVF stenosis.

关 键 词：药物涂层球囊 普通球囊 自体动静脉内瘘 狭窄 META分析 

分 类 号：R692.5[医药卫生—泌尿科学]