泮托拉唑、依卡倍特钠联合金银花对咽喉反流效果分析  

The Effect Analysis of Pantoprazole and Ecabet Sodium Combined with Honeysuckle Granules in Treating Laryngopharyngeal Reflux

作　　者：贾伊娜 Jia Yina(Department of Otorhinolaryngology,Head and Neck Surgery,the Second Affiliated Hospital of Dalian Medical University,Dalian 116000 China)

机构地区：[1]大连医科大学附属第二医院耳鼻咽喉头颈外科,辽宁大连116000

出　　处：《锦州医科大学学报》2021年第6期55-58,共4页Journal of Jinzhou Medical University

摘　　要：目的观察泮托拉唑、依卡倍特钠联合金银花颗粒对咽喉反流治疗的临床疗效,并初步探讨其在咽喉反流治疗过程中的临床意义。方法收集咽喉反流疾病患者186例,随机分成观察组(93例)和对照组(93例)。对照组给予口服泮托拉唑、依卡倍特钠治疗,观察组给予口服泮托拉唑、依卡倍特钠与金银花颗粒治疗,两组在治疗4 w、8 w后,分别比较分析反流症状评分量表(RSI)、体征评分量表(RFS)和临床疗效。结果泮托拉唑、依卡倍特钠联合金银花颗粒的观察组临床疗效明显优于口服泮托拉唑、依卡倍特钠的对照组。在接受药物规律治疗4 w、8 w后,对照组均比观察组RFS、RSI评分高,差异有统计学意义(P<0.05)。观察组患者的总有效率为94.62%,高于对照组患者的75.27%,二者之间比较差异有统计学意义(χ^(2)=13.622,P<0.05)。观察组患者不良反应发生率低于对照组患者,但二者差异无统计学意义(χ^(2)=0.522,P>0.05)。结论泮托拉唑、依卡倍特钠联合金银花颗粒观察组和泮托拉唑、依卡倍特钠对照组用药治疗后,RSI、RFS评分均较治疗前降低,且观察组治疗咽喉反流的临床疗效更为显著,推测泮托拉唑、依卡倍特钠联合金银花颗粒联合用药可能有效改善咽喉反流患者的临床症状。Objective To observe the clinical efficacy and preliminarily explore the clinical significance of pantoprazole,ecabet sodium combined with honeysuckle granules in treating laryngopharyngeal reflux.Methods 186 patients with laryngopharyngeal reflux were randomly divided into observation group(93 cases)and control group(93 cases).The control group was treated with oral pantoprazole and ecabet sodium,while the observation group was treated with oral pantoprazole,ecabet sodium and honeysuckle granules.After 4 and 8 weeks of treatment,the reflux symptom score scale(RSI),physical sign score scale(RFs)and clinical efficacy were compared and analyzed respectively.Results The clinical efficacy of pantoprazole and ecabet sodium combined with honeysuckle granules in the observation group was significantly better than that in the control group.After receiving regular drug treatment for 4 weeks and 8 weeks,the RFS and RSI scores of the control group were higher than those of the observation group,with statistically significant difference(P<0.05).The total effective rate of the observation group was 94.62%,which was higher than that of the control group(75.27%)and the difference was statistically significant(χ^(2)=13.622,P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,but the difference was not statistically significant(χ^(2)=0.522,P>0.05).Conclusion After treatment,the RSI and RFs scores of the observation group administered with pantoprazole,ecabet sodium combined with honeysuckle granules and those of the control group administered with pantoprazole and ecabet sodium were both lower than those before treatment,and the clinical efficacy of the observation group in the treatment of pharyngeal reflux was more obvious.It is speculated that the combination of pantoprazole,ecabet sodium and honeysuckle granules may effectively improve the clinical symptoms of patients with pharyngeal reflux.

关 键 词：泮托拉唑 依卡倍特钠 金银花颗粒 咽喉反流 

分 类 号：R766[医药卫生—耳鼻咽喉科]