新型抗肿瘤药物对甲状腺功能影响的研究进展  

Progress ontheeffectof novel drugs on thyroid function

作　　者：吕林林 陈庆松 董得时[1] LÜ Linlin;CHEN Qingsong;DONG Deshi(Depart-mentof Pharmacy,the First Affiliated Hospital of Dalian Medical University,Dalian 116011,China;不详)

机构地区：[1]大连医科大学附属第一医院药学部,辽宁大连116011 [2]大连医科大学药学院,辽宁大连116011

出　　处：《实用医学杂志》2021年第24期3101-3106,共6页The Journal of Practical Medicine

基　　金：国家自然科学基金面上项目(编号:62072070)。

摘　　要：随着新型抗肿瘤药物在临床上的广泛应用,其诱发的免疫相关不良反应也备受关注,其中甲状腺功能异常是最常见的不良反应之一。本文拟从免疫治疗和靶向治疗两类新型抗肿瘤药物对甲状腺功能影响的研究进展作一简要综述,以提高抗肿瘤药在癌症治疗期间的合理应用及用药安全性,减少药源性疾病,有助于提高肿瘤患者甲状腺功能的管理。With the wide application of novel anti⁃tumor drugs in clinical practice,the immune⁃related adverse reactions induced by them have also attracted much attention.Abnormal thyroid function is one of the most common adverse reactions.This paper is proposed to make a brief review of the research progress of the effects of two novel drugs on immunotherapy and targeted treatment,so as to improve the rational application of antineoplastic drugs and their safety during cancer treatment,to reduce drug⁃induced diseases,and contribute to a better manage⁃ment of thyroid function of patients.

关 键 词：甲状腺 药源性甲状腺疾病 抗肿瘤药物 

分 类 号：R969.3[医药卫生—药理学]