1,2-双(二叔丁基膦甲基)苯的合成  

Synthesis of 1,2-Bis(di-tert-butylphosphinomethyl)benzene

作　　者：陈辉[1] 王清福 周铎[1] 白东亚 张垚 屈凤波[1] 刘婷婷 CHEN Hui;WANG Qingfu;ZHOU Duo;BAI Dongya;ZHANG Yao;QU Fengbo;LIU Tingting(Institute of Chemistry,Henan Academy of Sciences,Zhengzhou 450002,China;Technology Center,China Tobacco Henan Industrial Co.,Ltd.,Zhengzhou 450000,China)

机构地区：[1]河南省科学院化学所有限公司,河南郑州450002 [2]河南中烟工业有限责任公司技术中心,河南郑州450000

出　　处：《信阳师范学院学报（自然科学版）》2022年第1期118-121,共4页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(22001060);河南省青年托举人才工程项目(2021HYTP005);河南省科学院科研开发项目(200503001,200603108,210503001,210403023,210603011)。

摘　　要：以氯代叔丁烷和亚磷酸二乙酯为原料制得二叔丁基氧化膦,用四氢铝锂还原得二叔丁基膦氢,经锂化后依次邻二氯苄反应合成了大位阻效应有机磷配体的1,2-双(二叔丁基膦甲基)苯。利用NMR核磁共振谱仪对其结构进行表征,并对反应收率的影响条件进行了优化。Di-tert-butyl phosphine oxide was prepared with chloro-tert-butane and diethyl phosphite as raw materials,and di-tert-butyl phosphine hydrogen was obtained by reduction with tetrahydroaluminum lithium.The structure of 1,2-bis(di-tert-butylphosphinomethyl)benzene,which is a large steric effect organophosphorus ligand,has been characterized by NMR analysis.And the reaction conditions of the key steps were optimized.

关 键 词：双膦配体 格氏反应 四氢铝锂 合成 

分 类 号：O621.3[理学—有机化学]