深度单采红细胞术治疗真性红细胞增多症患者的临床效果  

The Clinical Efficacy of Deep Erythrocyte Apheresis in the Treatment of Polycythemia Vera Patients

作　　者：李艳红[1,2,3] 聂波 罗丽[4,5] 贺振新 杨金荣 程沈菊[1,2,3] 罗珊 武坤[1,2,3] Li Yanhong;Nie Bo;Luo Li;He Zhenxin;Yang Jinrong;Cheng Shenju;Luo Shan;Wu Kun(Department of Clinical Laboratory,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Yunnan Provincial Key Laboratory of Laboratory Medicine,Kunming Yunnan 650032,China;Provincial Innovation Team of Clinical Laboratory Diagnosis,Kunming Yunnan 650032,China;Department of Hematology,The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China;Yunnan Provincial Research Center for Hematology,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院医学检验科,云南昆明650032 [2]云南省检验医学重点实验室,云南昆明650032 [3]临床检验诊断省创新团队,云南昆明650032 [4]昆明医科大学第一附属医院血液科,云南昆明650032 [5]云南省血液病研究中心,云南昆明650032

出　　处：《医疗装备》2021年第23期19-21,共3页Medical Equipment

基　　金：云南省教育厅科学研究基金项目(2020J0172);云南省技术厅科学研究基金项目[2018FE001(-200)]。

摘　　要：目的探讨深度单采红细胞术治疗真性红细胞增多症(PV)患者的临床疗效及安全性。方法选择2016年6月至2020年6月昆明医科大学第一附属医院血液科收治的28例PV患者作为研究对象,所有患者治疗前均经血液科医师评估,然后采用深度单采红细胞术进行治疗,比较治疗前、后的血常规指标[红细胞(RBC)、白细胞(WBC)、血红蛋白(Hb)、血细胞比容(HCT)、血小板(PLT)]水平变化,以及观察治疗期间的不良反应发生情况。结果治疗3次后,患者的RBC、Hb、HCT水平均低于治疗前,差异有统计学意义(P<0.05);患者的WBC、PLT水平与治疗前比较,差异均无统计学意义(P>0.05)。治疗期间,3例患者出现不良反应,其中2例为低钙血症,1例为血容量不足,予以对症处理症状缓解。结论采用深度单采红细胞术治疗PV患者的临床疗效显著,可明显改善红细胞增多症状,且安全性较高。Objective The clinical efficacy and safety of deep erythrocyte apheresis in the treatment of polycythemia vera(PV) patients were investigated. Methods A total of 28 PV patients admitted to the Department of Hematology, The First Affiliated Hospital of Kunming Medical University from June 2016 to June 2020 were selected as the study subjects. All patients were evaluated by hematologists before treatment, and then were treated with deep erythrocyte apheresis. The changes of blood routine indexes [red blood cell(RBC), white blood cell(WBC), hemoglobin(Hb), hematocrit(HCT)and platelet(PLT)] before and after treatment were compared and the occurrence of adverse reactions were observed during treatment. Results After 3 times of treatment, the levels of RBC, Hb and HCT were all lower than before treatment, and the differences were statistically significant(P<0.05);There were no significant differences in WBC and PLT levels before and after treatment(P>0.05). During the treatment, 3 patients developed adverse reactions, including 2 cases of hypocalcemia and 1 case of hypovolemia, which were relieved by symptomatic management. Conclusion Deep erythrocyte apheresis has a significant clinical efficacy on PV patients, with the symptoms of polycythemia improved obviously and high safety.

关 键 词：深度单采红细胞术 真性红细胞增多症 临床疗效 安全性 

分 类 号：R555[医药卫生—血液循环系统疾病]